方法：选取2015-11/2016-04就诊于我院的干眼症患者301例598眼，按年龄分为8组，分别为A～H组。应用眼表综合分析仪检查各组干眼症患者睑板腺腺体缺失情况、腺体形态变化、睑板腺开口阻塞及睑酯情况，分析比较各组之间的睑板腺变化规律。

结果：所有患者均有不同程度睑板腺腺体缺失，各组之间腺体缺失面积比较，差异有统计学意义(χ²=336，P<0.05)。A组腺体数目无减少，B～H各组之间腺体数目减少比较，差异有统计学意义(F=36.4357，P<0.05)。腺体形态从40岁开始逐渐变细，其与年龄呈反相关。睑板腺开口阻塞情况及睑酯的性状，各组之间无明显差异。

结论：眼表综合分析仪能客观精准地检查出干眼症患者的睑板腺情况，提供不同年龄段干眼症患者睑板腺变化规律的量化结果，为干眼症的病因诊断提供判断依据，指导临床治疗。

METHODS: There were divided into A to H groups according to age that 301 patients(598 eyes)with dry eye in our hospital of November 2015 to April 2016, a total of eight groups. We evaluated the condition of Meibomian gland of them through the OCULUS Keratograph, including the loss of the Meibomian gland, the shape of the Meibomian gland, eyelid ester and obstructed or not of the Meibomian gland orifices, etc.

RESULTS: There had lost of the Meibomian gland of all patients with dry eye in this study, the differences between the eight groups were statistically significant(χ²=336, P<0.05).The number of Meibomian gland of group A had no loss. The differences between the B～H groups were statistically significant(F=36.4357,P<0.05). Glands shape had become thin when the age was more than forty, getting worse as the growth of the age gradually. The differences eyelid ester and obstructed or not of the Meibomian gland orifices between the A～H groups were not statistically significant.

CONCLUSION: The OCULUS Keratograph can provide the objective and precise condition of Meibomian gland in each group of patients with dry eye for us, and the change rule of quantitative results. it can provide the diagnosing judgment for the patients of dry eye, and provide methods for clinical treatment.