方法：回顾性病例研究，选取2015-01/2016-06在秦皇岛市海港医院行黄斑区格栅样光凝治疗的DME患者188例376眼，治疗1mo后利用OCT检测黄斑区6mm范围内视网膜厚度，采用SPSS19.0统计软件对所得数据进行分析。

结果：格栅样光凝1mo后，患者黄斑中心凹至1mm、黄斑1～3mm、黄斑3～6mm平均视网膜神经上皮层厚度分别为332.02±18.07、393.40±19.71、372.00±20.01μm，与治疗前(404.70±16.37、445.17±18.25、410.87±18.14μm)比较，差异具有统计学意义(P<0.05)。三者厚度变化分别为72.68±14.74、51.77±9.48、38.87±17.94μm，组间及两两比较，差异具有统计学意义(P<0.05)。

结论：DME经格栅样光凝治疗1mo后黄斑区视网膜神经上皮层厚度降低，并且越接近黄斑中心凹处，降低作用越明显。

METHODS: This was a retrospective case study. We reviewed 188 patients(376 eyes)with diabetic macular edema(DME)treating by simple grid pattern laser photocoagulation in Haigang Hospital from January 2015 to June 2016. We measured retinal thickness of macular area within 6 mm scope by OCT at 1mo after laser treatment, analyzed the data using SPSS19.0 statistical software.

RESULTS: At 1mo after laser treatment, average macular retinal thickness with macular center fovea to 1mm at diameter, 1mm to 3mm, 3mm to 6mm is respectively 332.02±18.07, 393.40±19.71, 372.00±20.01μm. The average macular retinal thickness is respectively 404.70±16.37, 445.17±18.25, 410.87±18.14μm before treatment. Compared with before treatment, the difference is statistically significant(P< 0.05). The thickness change with macular center fovea to 1mm, 1mm to 3mm, 3mm to 6mm is respectively 72.68±14.74, 51.77±9.48, 38.87±17.94μm, the difference was statistically significant(P<0.05).

CONCLUSION: Macular area retinal thickness is reduced at 1mo after simple grid pattern laser photocoagulation, the effect is more obvious when closer to macular center fovea.