[关键词]
[摘要]
目前，在大量研究中已发现多种microRNA分子，它们在视网膜神经上皮、晶状体、角膜和视网膜色素上皮中均有特异性表达。其中miR-126在肿瘤细胞的增殖、胸腺淋巴细胞的发育、心血管疾病中发挥一定的作用。有些实验表明miR-126与角膜新生血管的形成、糖尿病视网膜病变的发展及免疫系统相关的眼科疾病均有一定的相关性。本文就当前miR-126在眼科疾病中的作用机制及研究进展作一综述。
[Key word]
[Abstract]
Up to now, a variety of microRNAs have been found in a number of studies, that specifically expressed in retinal neuroepithelial, lens, cornea and retinal pigment epithelium, in which miR-126 plays a certain role in the proliferation of tumor cells, the development of thymus lymphocytes and cardiovascular diseases. Some researches show that miR-126 has certain correlations with the formation of corneal neovascularization, the development of diabetic retinopathy, and the immune system related eye disease. In this paper, the current miR-126 in the role of eye disease mechanism and research progress were reviewed.
[中图分类号]
[基金项目]
国家自然科学青年基金项目(No.81300728); 黑龙江省教育厅面上项目(No.12541516)
