方法：根据不同植入手术将150例150眼难治性青光眼患者分为A组(Ex-press青光眼引流器植入术)与B组(Ahmed青光眼阀植入术)，比较两组患者不同时间点眼压、抗青光眼药物变化、手术成功率、视力改善和并发症情况。

结果：两组患者术后1d，1wk，3、6、12mo眼压较术前均显著下降(P<0.05)； A组术后3、6、12mo眼压均显著低于B组，术后6、12mo抗青光眼药物数目均显著少于B组，差异有统计学意义(P<0.05)； 两组患者术后12mo手术成功率、视力提高率和术后并发症发生率比较，差异均无统计学意义(P>0.05)。

结论：Ex-press青光眼引流器植入术和Ahmed青光眼阀植入术治疗难治性青光眼疗效类似，但前者术后控压效果更好，抗青光眼药物使用数目少。

METHODS:A total of 150 patients with refractory glaucoma(150 eyes)were divided into Group A(treated by implantation with Ex-press glaucoma drainage device)and Group B(treated by implantation with Ahmed glaucoma valve)according to different implantation methods. Changes of intraocular pressure and anti-glaucoma drugs at different time points, the success rate of surgery, improvement of visual acuity and complications were compared between the two groups.

RESULTS: The intraocular pressure of two groups at 1d, 1wk, 3, 6 and 12mo after surgery was significantly lower than that before surgery(P<0.05). The intraocular pressure of Group A at 3, 6 and 12mo after surgery was significantly lower than that of Group B, while anti-glaucoma drugs at 6 and 12mo after surgery were significantly fewer than those in Group B at the same time point(P<0.05). There were no significant differences between the two groups in 12-month success rate of operation, improvement rate of visual acuity and incidence of postoperative complications(P>0.05).

CONCLUSION:The effects of implantation with Ex-press glaucoma drainage device are similar to those of implantation with Ahmed glaucoma valve in the treatment of refractory glaucoma. However, the intraocular pressure control effect of the former is better than the latter, and used anti-glaucoma drugs are fewer.