目的：评估马来西亚东西部三级医院感染性角膜炎流行病学及发病因素。

方法：收集来自马来西亚西部Sungai Buloh医院、吉隆坡综合医院和东部Queen Elizabeth医院、沙捞越州综合医院的感染性角膜炎患者207例。研究记录了危险因素。进行角膜刮片镜检和培养。

结果：马来西亚西部感染性角膜炎最普遍的风险因素是植物性损伤(28.5%)和非植物性损伤(18.3%)。27.7%的创伤病例与工作有关，其中外籍男性工作者占34.2%。马来西亚东部最普遍的风险因素是配戴隐形眼镜(32.9%)。马来西亚东西部绿脓假单胞菌是感染性角膜炎最常见的病菌。马来西亚西部最常见的真菌病原体是镰刀菌，占所有阳性真菌培养物的60%。

结论：马来西亚东西部公立医院细菌性角膜炎检出率较高，而东部隐形眼镜配戴则是常见风险因素(P<0.05)，西部真菌性角膜炎检出率高。

METHODS: A total of 207 patients were enrolled. Patients referred for microbial keratitis to Sungai Buloh Hospital and Kuala Lumpur Hospital in West Malaysia and Queen Elizabeth Hospital and Kuching General Hospital in East Malaysia were recruited. Risk factors were documented. Corneal scrapings for microscopy and culture were performed.

RESULTS: The most common risk factor in West Malaysia was organic trauma(28.5%)followed by non organic trauma(18.3%); 27.7% of trauma cases was work related with 34.2% involving male foreign workers. The most common risk factor in East Malaysia was contact lens wear(32.9%). Pseudomonas aeruginosa was the most common organism isolated in both places. The most common fungal pathogen in West Malaysia was Fusarium spp representing 60% of all positive fungal cultures.

CONCLUSION: In West Malaysia organic trauma was the most common risk factor seen in public hospitals here whereas, contact lens wear was the most common risk factor in East Malaysia(P<0.05). Fungal keratitis was more commonly seen in West Malaysia.