目的：评价妥布霉素地塞米松眼膏治疗睑缘炎的疗效和安全性。

方法：计算机检索Pubmed、Medline、Embase、Elsevier、Cochrane Library、万方、中国知网、中国科技期刊全文数据库、中国生物医学文献数据库等数据库，手工检索灰色文献，并用Google搜索相关文献。从有效率、眼压、不良反应等方面进行系统评价，并提取有效数据进行Meta分析。

结果：共有8个符合要求的随机对照研究纳入，患者共970例。试验组和对照组比较结果显示试验组有效率高于对照组，差异具有统计学意义(RR=1.75，95%CI=1.29～2.37，P=0.0003)； 试验组眼压高于对照组，差异具有统计学意义(SMD=1.30，95%CI=0.85～1.75，P<0.00001)； 两组的不良反应(眼睑水肿、结膜充血、眼压升高、眼睑刺痒、过敏反应)差异无统计学意义(RR=1.64，95%CI=0.86～3.10，P=0.13)。

结论：妥布霉素地塞米松眼膏治疗睑缘炎有效，且不增加治疗的不良反应。但由于纳入的文献总体质量不高，尚仍需严谨的高质量的随机对照试验进一步证实。

METHODS: We searched in Pubmed, Medline, Embase, Elsevier, Cochrane Library, Wangfang database, CNKI, VIP database, Sinomed database, and gray literature were performing manual. The efficiency, intraocular pressure, adverse reactions and extract valid data were evaluated.

RESULTS: Totally 8 controlled trials were enrolled, including 970 patients. Compared with control groups, the efficiency and the intraocular pressure in experiment group had a statistically significant increase(RR=1.75, 95%CI=1.29-2.37, P=0.0003; SMD=1.30, 95%CI=0.85-1.75, P<0.00001), and there was no statistic difference in adverse reactions(RR=1.64, 95%CI=0.86-3.10, P=0.13).

CONCLUSION: Tobramycin and dexamethasone ointment in treatment of blepharitis is effective with no adverse effects. Due to the quality of the literature is low, there is still need high quality randomized controlled trials.