[关键词]
[摘要]
骨髓间充质干细胞(bone marrow mesenchymal stem cell，BMSC)可在体内外培养诱导分化为角膜上皮细胞、角膜缘上皮细胞和角膜基质细胞等。BMSC移植后可分化为角膜上皮细胞，有效修复损伤的角膜上皮细胞组织，能表达多种细胞因子，减少炎症细胞浸润，减轻细胞损伤，并抑制细胞凋亡，降低角膜移植后的排斥反应； BMSC还能分化促进角膜缘干细胞增殖。也可在载体上利用BMSC构建生物角膜，进行眼表修复，此为基础研究提供了新的研究方向，为临床治疗角膜损伤类疾病提出了新的临床治疗思路，在基础研究和临床运用方面都有非常巨大的潜力和广阔的前景。本文就BMSC在角膜损伤修复中的研究现状和进展进行综述。
[Key word]
[Abstract]
Bone marrow mesenchymal stem cells(BMSCs)are a class of cells that can differentiate into different kind of corneal cells both in vitro and in vivo, which include corneal epithelial cells, limbal epithelial cells and corneal stromal cells. BMSCs could differentiate into corneal epithelial cells after transplantation, which can not only repair the damaged corneal, but also relieve inflammatory injury caused by the inflammatory cell infiltration. The other function of BMSC transplantation is to reduce the rejection after corneal transplantation by inhibiting cell damage and apoptosis. BMSC can also express a variety of factors on the carrier, these factors paly the important role in promoting the proliferation of limbal stem cells. These findings above provide a new direction for the fundamental study of ophthalmology, and put forward new clinical treatment ideas for corneal disease, both of them have broad protect for development. In this paper, the research status and progress of BMSC in the repair of corneal injury are reviewed.
[中图分类号]
[基金项目]
云南省科技厅-昆明医科大学应用基础研究联合专项(No.2014FB074)
