Anti-vascular endothelial growth factor(VEGF)drugs can effectively treat the diseases which related with the formation of pathological angiogenesis. However, after the intravitreal injection of anti-VEGF drugs, the distribution of this drugs in our eyes will have certain impact on different organizations, due to its specifical mechanism of action. Previously, the studies mainly concentrated on the structures which are rich in vascular tissues. Nevertheless, the structures which are lack of vascular tissues is often overlooked. This article viewed the influence of lens after intravitreal injection of anti-VEGF drugs on early development of the lens, and when it was injected during or after the cataract operation.