目的：评估翼状胬肉患者血清总抗氧化能力与对照组的比较结果。

方法：病例对照研究。包括2016年Vali-Asr教学医院眼科患有翼状胬肉的所有患者。对照组来源于Vali-Asr教学医院眼科(非翼状胬肉患者)，两组年龄、性别和居住地无统计学差异。通过任意抽样选取66例受试者\〖31(47%)例患者，35(53%)例对照组\〗。用铁还原抗氧化法(FRAP)检测所有患者静脉血液样本。FRAP是一种10min快速检测手段，通过检测样本使铁(Fe³⁺)转化为亚铁(Fe²⁺)的能力以测定样本的抗氧化能力。通过SPSS 21软件收集数据，使用chi-square 和 Mann-Whitney 进行分析(α=0.05)。

结果：研究组患者平均抗氧化能力为842.55±161.46 μmol/L，对照组为856.77±209.41 μmol/L(P=0.8)。基于性别比较正常个体与翼状胬肉患者平均血清抗氧化能力，结果显示对照组男性平均抗氧化能力为894.05±176.82 μmol/L，女性为780.01±118.33 μmol/L，差异具有统计学意义(P=0.008)。病例组与对照组的同性别间对比结果无显著性差异。

结论：研究结果显示，翼状胬肉患者血清抗氧化能力的总水平低于对照组的平均值，但未观察到显著差异。本研究结果与氧化应激在翼状胬肉发病机制中的影响基本一致。

METHODS: This case-control study was conducted on all persons referred to Ophthalmology Clinic of teaching Hospital of Vali-Asr(peace upon to him)with clinical symptoms of pterygium during the year 2016. The control group was selected among patients referred to the Ophthalmology Clinic of Vali-Asr(peace without pterygium)that the two groups were matched in terms of age, gender and place of residence. Sixty-six persons \〖31 people(47%)in patient group and 35 people(53%)in the control group\〗 were enrolled by convenience sampling. Venous blood sample was taken from all patients after the sampling using ferric reducing antioxidant power(FRAP); FRAP- as a quick 10min measurement, the antioxidant power measurement of samples according to the conversion of ferric iron(Fe³⁺)to ferrous iron(Fe²⁺)was checked. The collected data ware entered to software SPSS 21 and were analyzed by chi-square and Mann-Whitney tests at the level of α =0.05.

RESULTS: The mean of antioxidant capacity in patients was 842.55±161.46 μmol/L and antioxidant capacity in healthy controls was 856.77±209.41 μmol/L(P=0.8). In the comparison of mean serum antioxidant capacity in healthy individuals and in the serum of people with pterygium based on gender the results showed that the antioxidant capacity mean in male control subjects has been 894.05±176.82 μmol/L and in females control 780.01±118.33 μmol/L that the observed difference have been reported statistically significant(P=0.008)but the other comparison according the gender between cases and control does not show any significant difference.

CONCLUSION: The results of this study showed that the full level of serum antioxidant capacity in patients has been less than the mean of antioxidant capacity in control subjects, however the observed difference has not been significant. The results of this study were consistent with basic results carried out on the damaging effects of oxidative stress in the pterygium pathogenesis. Recommending diet with minerals and vitamins containing antioxidants may be preventing the onset and progression of pterygium.