[关键词]
[摘要]
热休克蛋白(heat shock protein，HSP)是细胞受到不同刺激时产生的一组高度表达的蛋白。这种蛋白在结构上高度保守，在功能上常被认为具有保护细胞的作用。近年来，有研究表明HSP27和HSP70具有保护视网膜视神经细胞的作用，而其相关抗体具有促进这些细胞凋亡的作用。在细胞培养和动物实验中，我们观察到阻断HSP27抗体和HSP70抗体的表达有利于保护视网膜视神经细胞。本文就HSP27和HSP70与视网膜视神经疾病的关系作一综述。
[Key word]
[Abstract]
Heat shock protein(HSP)is a family of high expressed proteins under the different stimulus. This family is highly conserved in structure and can protect cells in function. In recent years, there are some researches illustrate that HSP 27 and HSP 70 have protective effect on retinal cells and optical nerve cells, while the HSP-27 Ab and HSP-70 Ab can promote the apoptosis of these cells. In the cell culture and animal experiment, we have observed that it is beneficial to protect retinal cells and optical cells through blocking the express of HSP-27 Ab and HSP-70 Ab. This article reviews the relationship between HSP 27 and HSP 70 with retinal diseases and optical nerve diseases.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81260153)
