目的：比较飞秒激光小切口角膜基质透镜取出术(small incision lenticule extraction，SMILE)、飞秒辅助LASIK术(FS-LASIK)两种手术方式术后眼压和角膜生物力学指标的变化。

方法：选取我院自愿接受SMILE手术101例202眼和FS-LASIK手术101例202眼近视患者，分别于术前、术后1mo应用眼反应分析仪(ocular response analyzer，ORA)检测角膜补偿眼压(corneal compensated intraocular pressure，IOPcc)、模拟Goldmann眼压(Goldmann correlated IOP value，IOPg)、角膜阻力因子(corneal resistance factor，CRF)、角膜滞后量(corneal hysteresis，CH)。比较术后1mo与术前测量值的差异，两组CRF、CH降低值的差异。

结果：术后1mo SMILE组IOPcc、IOPg分别为13.84±2.22、10.81±2.52mmHg，较术前16.15±2.90、15.95±3.08mmHg显著降低(t=-13.58、-32.91，均P<0.01)。CRF、CH术后测量值7.52±1.41、8.66±1.19mmHg较术前10.72±1.61、10.60±1.43mmHg显著降低(t=-41.21、-24.03，均P<0.01)。CRF、CH分别较术前降低3.19±1.10、1.93±1.14mmHg。FS-LASIK组术后1mo IOPcc、IOPg分别为13.99±2.33、10.10±2.55mmHg，较术前15.88±3.29、14.86±3.34mmHg显著降低(t=-10.09、-23.00，均P<0.01)。CRF、CH术后测量值6.68±1.14、7.90±1.27mmHg较术前9.93±1.85、9.98±1.60mmHg显著降低(t=-24.84、-18.90，均P<0.01)。CRF、CH分别较术前降低3.25±1.86、2.08±1.57mmHg。CRF、CH术后降低值SMILE 组显著小于FS-LASIK组(t=-0.351、-1.081，均P<0.01)。

结论：两种手术方式术后角膜生物力学和眼压测量值均较术前显著降低。CRF、CH术后降低值，SMILE 组显著低于FS-LASIK组。

METHODS: Preoperatively, 1mo after surgery, 101 patients(202 eyes)with myopia in each group respectively by SMILE and FS-LASIK were examined by ocular response analyzer(ORA). Parameters were compared between postoperative(1mo)and preoperative. Comparisons included the corneal thickness and corneal compensated intraocular pressure(Iopcc), Goldmann correlated IOP value(Iopg), corneal resistance factor(CRF), corneal hysteresis(CH).

RESULTS: SMILE group: IOPcc, IOPg(1mo postoperatively, 13.84±2.22,10.81±2.52mmHg)significantly changed comparing with preoperative(16.15±2.90, 15.95±3.08mmHg; t=-13.58, -32.91; both P<0.01). CRF and CH(1mo postoperatively, 7.52±1.41, 8.66±1.19mmHg)significantly changed comparing with preoperative(10.72±1.61, 10.60±1.43; t=-41.21, -24.03; both P<0.01). The difference were 3.19±1.10, 1.93±1.14mmHg respectively. FS-LASIK group: Iopcc and Iopg(1mo postoperatively, 13.99±2.33, 10.10±2.55mmHg)significantly changed comparing with preoperative(15.88±3.29, 14.86±3.34mmHg; t=-10.09、-23.00; both P<0.01). CRF, CH(1mo postoperaturely, 6.68±1.14, 7.90±1.27mmHg)significantly changed comparing with preoperative(9.93±1.85, 9.98±1.60mmHg; t=-24.84, -18.90; both P<0.01). The difference were 3.25±1.86, 2.08±1.57mmHg respectively. Changes of CRF and CH were significantly different between two groups(t=-0.351, -1.081; both P<0.01).

CONCLUSION: The postoperative corneal biomechanics and IOP measurements are lower than preoperative. SMILE are lower than FS-lasik in changes of CRF, CH.