目的：探讨飞秒激光LASIK术后角膜生物力学指标的改变，为飞秒激光LASIK术的安全性研究提供理论依据。

方法：选取2014-06/2016-06于我院行手术治疗的85例170眼近视患者，所有患者均采用飞秒激光LASIK术治疗，对符合纳入标准的病历资料进行回顾性分析。术前和术后3、6mo采用眼反应分析仪测量角膜补偿眼压(corneal compensated intraocular pressure，IOPcc)、角膜阻力因子(corneal resistance factor，CRF)、角膜滞后量(corneal hysteresis，CH)以及模拟Goldmann眼压(Goldmann correlated IOP value，IOPg)，采用A型超声测量仪测量中央角膜厚度。

结果：术后3、6mo中央角膜厚度显著低于术前，差异有统计学意义(P<0.05)； 术后3、6mo时IOPcc、CRF、CH、IOPg等角膜生物力学指标均显著低于术前，差异有统计学意义(P<0.05)； 术后3、6mo各指标比较，差异无统计学意义(P>0.05)； 角膜切削厚度为98.67±7.56μm，CH和CRF变化量分别为3.40±0.34mmHg、3.55±0.43mmHg，角膜切削厚度与CH、CRF变化量呈明显正相关(r=0.232、0.254，P<0.001)。

结论：飞秒激光LASIK术后角膜厚度显著降低，术后各项角膜生物力学指标均显著下降，且3mo后基本趋于稳定。

METHODS: Totally 85 myopia patients(170 eyes)treated in our hospital from June 2014 to June 2016 were selected and underwent femtosecond laser LASIK surgery. The medical records of patients met the inclusion criteria were retrospectively analyzed. Corneal compensated intraocular pressure(IOPcc)and corneal resistance factor(CRF), corneal hysteresis(CH)and Goldmann correlated to IOP value(IOPg)before operation, and at 3 and 6mo after surgery were measured by the ocular response analyzer, and central corneal thickness was measured by A type ultrasonic measuring instrument.

RESULTS: At postoperative 3 and 6mo, central corneal thickness was sharply lower than that before surgery, with a statistical significance(P<0.05); postoperative IOPcc, CRF, CH, IOPg and other corneal biomechanical parameters decreased distinctively, with statistical meaning(P<0.05); data at postoperative 3 and 6mo showed no evident differences(P>0.05); the cornea cutting thickness was 98.67±7.56μm, CH and CRF variation were 3.40±0.34mmHg, 3.55±0.43mmHg respectively, the cornea cutting thickness was positively correlated with CH, CRF variation(r=0.232, 0.254; P<0.001).

CONCLUSION: Femtosecond laser LASIK can apparently reduce corneal thickness as well as the corneal biomechanical indexes, the data at postoperative 3mo tends to be stable.