目的：比较患单侧特发性全层黄斑裂孔(FTMH)眼、对侧眼以及正常对照组黄斑脉络膜厚度。

方法：横断面研究。选取30例单侧特发性全层黄斑裂孔马来西亚患者，以及年龄、性别、种族相匹配的正常对照组。用激光干涉法测量研究对象眼轴长度。利用谱域光学相干层析成像技术获取增强深度成像光学相干断层成像。在黄斑中心凹处，距中心凹1 mm和 2 mm鼻侧、颞侧、上方、下方测量脉络膜厚度。采用独立统计分析法、配对样本t-tests、chi-square tests和Pearson相关性检验进行数据分析。

结果：全层黄斑裂孔组平均中心凹脉络膜厚度为201.0±44.0 μm，对侧眼平均为225.3±51.4 μm，对照组为262.3±70.3 μm。相较于对照组，全层黄斑裂孔各部位脉络膜较薄(P<0.05)。对侧眼组除了鼻侧1 mm 和2 mm处，其余地方脉络膜厚度较对照组薄(P<0.05)。全层黄斑裂孔组脉络膜厚度低于对侧眼组，但两组间差异无统计学意义(P>0.05)。脉络膜厚度通常在中心凹处最高，在鼻侧最低。黄斑中心凹脉络膜厚度与年龄(r=-0.278， P=0.032)和眼轴长度(r=-0.328， P=0.011)呈负相关。

结论：单侧全层黄斑裂孔患眼与对侧眼和健康对照组相比，脉络膜厚度较低。

METHODS: Cross-sectional study. Thirty patients with unilateral idiopathic FTMH and thirty age, sex, and race-matched controls were recruited. Axial lengths were measured using laser interferometry. Enhanced depth imaging optical coherence tomography images were obtained using Heidelberg spectral-domain optical coherence tomography. Choroidal thickness was measured at the fovea, and at 1 mm and 2 mm nasally, temporally, superiorly and inferiorly from the center of the fovea. Statistical analysis was performed using independent and paired t-tests, chi-square tests, and Pearson correlation tests(P<0.05).

RESULTS: The mean subfoveal choroidal thickness was 201.0±44.0 μm in the FTMH group, 225.3±51.4 μm in the fellow eye group and 262.3±70.3 μm in the control group. The choroid was thinner in FTMH eyes at all locations when compared to control eyes(P<0.05). The fellow eye group also had thinner choroids than the control group at all locations except at 1 mm and 2 mm nasal to the fovea(P<0.05). Choroidal thickness in the FTMH group was lower than in the fellow eye group, but the differences were not statistically significant(P>0.05). Choroidal thickness was generally highest subfoveally and lowest nasally. Subfoveal choroidal thickness was negatively correlated with age(r=-0.278, P=0.032), and axial length(r=-0.328, P=0.011).

CONCLUSION: Choroidal thickness is lower in both eyes of patients with unilateral FTMH compared to healthy control eyes.