目的：探究普拉洛芬滴眼液联合小牛血去蛋白提取物滴眼液治疗中重度干眼的临床效果。

方法：选取2016-01/2017-01在郑州市第二人民医院接受治疗的中重度干眼患者84例132眼。按随机数字表法分为对照组42例68眼，观察组42例64眼，其中对照组采用聚乙烯醇滴眼液联合普拉洛芬滴眼液治疗，观察组采用普拉洛芬滴眼液联合小牛血去蛋白提取物滴眼液治疗。在治疗前及治疗后记录患者主客观评分。

结果：治疗前两组患者FL、BUT、SⅠt、视力4个客观指标组间比较差异无统计学意义(P>0.05)。两组患者治疗后干眼症状评分均较治疗前显著下降，组内比较差异有统计学意义(P<0.05)； 治疗后观察组较对照组干眼症状评分均显著下降，差异有统计学意义(P<0.05)。两组治疗后FL评分治疗前显著下降、BUT、SⅠt、视力指标较治疗前显著上升，组内比较差异有统计学意义(P<0.05)； 治疗后，各指标组间比较差异有统计学意义(P<0.05)，说明观察组受试者治疗后客观症状改善优于对照组。所有患者均未出现严重不良反应，安全性较好。

结论：普拉洛芬滴眼液联合小牛血去蛋白提取物滴眼液治疗中重度干眼的临床效果较好，且安全性有保证。

METHODS: A total of 84 patients(132 eyes)who received treatment at the Zhengzhou Second Hospital were selected from January 2016 to January 2017. According to random number table method they were divided into control group 42 cases(68 eyes)and observation group 42 cases(64 eyes), the control group using polyvinyl alcohol eye drops with pranoprofen, observation group with pranoprofen with deproteinized extract of calf blood eye drops. Subjective and objective scores before and after treatment were recorded.

RESULTS: There was no statistically significant difference on the four objective indicators of pretreatment FL, BUT, SⅠt, and vision between the two groups(P>0.05). Dry eye symptom scores of the two groups decreased after treatment, both with significantly different(P<0.05); after treatment, the symptom scores of the observation group were significantly lower than those in the control group, and the difference was statistically significant(P<0.05), indicating that the subjective symptoms of the observation group were better than that of the control group after treatment. After treatment of the control group and the observation group, the FL index was significantly lower than before treatment, BUT, SⅠt and vision were significantly higher than before treatment, and the differences within either group were statistically significant(P<0.05); those indexes of observation group were different compared with control group(P<0.05), indicating that the objective symptoms of the observation group were better than that of the control group after treatment. None of the patients showed serious adverse reactions.

CONCLUSION: The clinical effect of praprofen on the treatment of moderate to severe dry eye with the deproteinized calf blood extract is better.