目的：探讨3g/L玻璃酸钠滴眼液联合盐酸溴己新片治疗蒸发性干眼的临床疗效。

方法：选取200例400眼蒸发性干眼患者随机分为对照组(n=100)和观察组(n=100)，两组患者均给予3g/L玻璃酸钠滴眼液及物理治疗，在此基础上，观察组患者口服盐酸溴己新片。比较两组患者治疗前后泪液中炎症因子(IL-6、IL-10、TNF-α和IL-1β)水平、OSDI、BUT、SⅠt、FL，并评估临床疗效和不良反应。

结果：治疗后，两组患者IL-6、IL-10、TNF-α、IL-1β、OSDI和FL评分较治疗前均明显降低，BUT和SⅠt较治疗前均明显升高，且在观察组中以上指标的水平改善程度均优于对照组，差异有统计学意义(P<0.05)。观察组临床总有效率高于对照组， 差异有统计学意义(χ²=5.531，P=0.019)，而两组患者的不良反应发生率比较差异无统计学意义(χ²=0.307，P=0.579)。

结论：3g/L玻璃酸钠滴眼液联合盐酸溴己新片治疗蒸发性干眼可明显降低干眼症患者泪液中的炎症因子水平，改善眼部症状评分，提高临床的总有效率，且不增加治疗相关的不良反应。

METHODS:Totally 200 patients with dry eye were randomly divided into the control group(n=100)and observation group(n=100). Patients in two groups were given 3g/L sodium hyaluronate eye drops and physiotherapy. On the basis of this, the observation group were treated with bromhexine hydrochloride tablets. The inflammatory factors(IL-6, IL-10, TNF-α and IL-1β)levels and ocular symptom scores(OSDI, BUT, SⅠt, FL)in the two groups were compared between before and after treatment. And the clinical efficacy and adverse reactions were evaluated.

RESULTS: After treatment, the IL-6, IL-10, TNF-α, IL-1β, OSDI and FL scores in two groups were significantly lower than those before treatment, and BUT and SⅠt were significantly higher than those before treatment. Moreover, the improvement degree of the above indexes in the observation group were better than those in the control group, showing statistically significant difference(P<0.05). The total effective rate of the observation group was higher than that of the control group(χ²=5.531, P=0.019), but there was no significant difference in the incidence of adverse reactions between the two groups(χ²=0.307, P=0.579).

CONCLUSION:As for the patients with dry eye, the combination of 3g/L sodium hyaluronate eye drops with bromhexine hydrochloride tablets can significantly decrease the level of inflammatory factors, improve the eye symptoms and the clinical total efficiency, without increasing treatment-related adverse effects.