目的：比较不同设备在中央角膜厚度(CCT)测量方面的异同，为临床提供一种安全、有效、简便、准确的角膜厚度测量方法。

方法：连续入选2016-09/12于上海中医药大学附属普陀医院眼科行术前检查的白内障患者95例95眼，分别采用手持式自动PachPen超声角膜测厚仪、眼前节光学相干断层扫描仪(AS-OCT)及角膜内皮镜测量中央角膜厚度，并同时测量眼压。观察三种不同设备在中央角膜厚度测量方面的异同及其与眼压的相关性，并行统计学分析。

结果：PachPen超声角膜测厚仪测量CCT为544.43±36.61μm，AS-OCT测量CCT为527.09±35.54μm，角膜内皮镜测量CCT为533.20±30.17μm，三组比较差异具有统计学意义(F=6.272，P=0.002)，PachPen超声角膜测厚仪测出的CCT较另外两组显著增高。三者与眼压的相关系数分别为0.290、0.277和0.204(P<0.05)，其中PachPen超声角膜测厚仪测出的CCT与眼压之间的相关性最高。三种测量方法测得的CCT之间均显著相关(P<0.001)。

结论：PachPen超声角膜测厚仪测量出的中央角膜厚度最厚，其次是角膜内皮镜，AS-OCT测量值最小，三种设备测量中央角膜厚度有明显相关性和较好的一致性，与眼压均具有相关性，临床上应予以重视。

METHODS: Totally 95 eyes of 95 cataract patients enrolled continuously for preoperative examination in ophthalmology department of Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from September 2016 to December 2016. Handheld automatic PachPen ultrasonic pachymetry(USP), anterior segment optical coherence tomography(AS-OCT)and specular microscopy were respectively used to measure the central corneal thickness, and intraocular pressure was measured at the same time. The similarities and differences of these three different devices to measure the central corneal thickness and their correlations with intraocular pressure were observed. Then the data were analyzed statistically.

RESULTS: The CCT value measured by PachPen ultrasonic pachymetry was 544.43±36.61μm, the CCT value measured by AS-OCT was 527.09±35.54μm, and the CCT value measured by specular microscopy was 533.20±30.17μm. There was significant difference between these three groups(F=6.272, P=0.002), and the CCT value measured by PachPen ultrasonic pachymetry was significantly higher than the other two groups. The correlation coefficients between the CCT values of these three groups and intraocular pressure were 0.290, 0.277 and 0.204(P<0.05)respectively, of which the correlation between the CCT measured by PachPen ultrasonic pachymetry and the intraocular pressure was the highest. There was statistically significant correlation between the CCT values measured by these three measurements(P<0.001).

CONCLUSION: The CCT value measured by PachPen ultrasonic pachymetry is the highest. The second CCT value is measured by specular microscopy, and the smallest CCT value is measured by AS-OCT. Obvious correlation and good consistency were found in the CCT values measured by three types of devices, and the CCT values were all correlated with intraocular pressure. Therefore, we should take more attention in clinic.