目的：研究2型糖尿病患者糖尿病性视网膜病变(diabetic retinopathy，DR)与干眼的相关性。

方法：选取2015-08/2017-02于我院眼科门诊就诊的干眼患者资料，其中2型糖尿病无DR患者50例100眼，合并非增殖性视网膜病变者(nonproliferative diabetic retinopathy，NPDR)50例100眼、合并增殖性视网膜病变者(proliferative diabetic retinopathy，PDR)50例100眼，非糖尿病的干眼患者50眼作为对照组。分别行眼表疾病指数(ocular surface disease index，OSDI)问卷、泪液分泌试验(Schirmer I test，SⅠt)、泪膜破裂时间(break-up time，BUT)和角膜荧光染色(fluorescein staining，FL)检查。比较三组糖尿病患者干眼的患病率及各组干眼程度的差异性。

结果：2型糖尿病患者中无DR眼、合并NPDR眼、合并PDR眼的干眼患病率分别为：44%、51%、59%。无DR干眼患者与对照组干眼程度、OSDI、SⅠt、BUT、FL差异均无统计学意义(P>0.05)。NPDR干眼患者较无DR干眼患者干眼程度更严重，OSDI、SⅠt、BUT、FL差异均有统计学意义(P<0.05)； PDR干眼患者较NPDR干眼患者干眼程度更严重，SⅠt、BUT、FL差异均有统计学意义(P<0.05)，但OSDI评分低，与无DR干眼患者差异无统计学意义(P>0.05)。

结论：2型糖尿病患者随着DR的发生与进展，干眼的患病率增加，干眼的严重程度也增加，但严重DR患者眼表不适症状可能减轻。

METHODS:A total of 150 patients with type 2 diabetes mellitus collected from August 2015 to February 2017 were separated to three groups: without diabetic retinopathy(DR), with nonproliferative diabetic retinopathy(NPDR)and with proliferative diabetic retinopathy(PDR). Each group contained 50 cases(100 eyes). Another 50 dry eye patients without diabetes were as control. All patients were provided with questionnaire survey of ocular surface disease index(OSDI), SchirmerⅠtest(SⅠt), break-up time(BUT)and fluorescein staining(FL), to compare the prevalence and the severity of dry eye in these groups.

RESULTS: The prevalence of dry eye in type 2 diabetes mellitus patients without DR group was 44%, in type 2 diabetes mellitus patients with NPDR group was 51% and in type 2 diabetes mellitus patients with PDR group was 59%. To compare dry eye patients without DR with the control group, there were no difference in OSDI, SIt, BUT and FL(P>0.05). Dry eye in the patients with NPDR was more serious than in the patients without DR, there were statistical difference in OSDI, SⅠt, BUT and FL(P<0.05). Dry eye in the patients with PDR was more serious than in the patients with NPDR, there were statistical difference in SIt, BUT and FL(P<0.05). But OSDI was lower and showed no difference with patients without DR(P>0.05).

CONCLUSION: The incidence and the severity of dry eye increase gradually with the occurrence and development of diabetic retinopathy in type 2 diabetes mellitus patients. However, the symptoms may be reduced in patients with severe DR.