目的：观察中药“四黄清灵液”熏蒸联合人工泪液治疗干眼症的临床疗效，为临床治疗干眼症提供依据。

方法：选取2016-06/12我院眼科就诊的干眼患者82例164眼，随机分为对照组与观察组。对照组41例82眼给予人工泪液滴双眼，4次/d； 观察组41 例82眼在给予人工泪液基础上增加自拟中药“四黄清灵液”(黄精、黄岑、黄连、菊花、薄荷)熏蒸双眼，1次/d。治疗前及连续治疗14d 后，分别观察两组患者泪膜破裂时间(break-up time，BUT)、角膜荧光素染色(corneal fluorescein staining，FL)、基础泪液分泌试验(Schirmer Ⅰ test，SⅠt)以判断疗效变化。

结果：治疗14d后，观察组总有效率为87.8%，对照组总有效率为70.7%，两组之间比较差异有统计学意义(P<0.05)。治疗14d后观察组SⅠt(8.43±2.51mm/5min)、BUT(8.60±2.47s)较对照组(6.38±2.52mm/5min、6.35±2.29s)升高，差异有统计学意义(P<0.05)； 治疗14d后观察组FL 评分(0.84±0.75分)低于对照组(1.26±0.84分)，差异有统计学意义(P<0.05)。

结论：自拟中药“四黄清灵液”熏蒸联合人工泪液治疗干眼疗效优于单纯使用人工泪液，可有效改善干眼症患者的临床症状。

METHODS: Totally 82 patients(164 eyes)were randomly divided into two groups from June 2016 to December 2016 in Ophthalmology Department of our hospital. The patients in control group were given artificial tears; the patients in the observation group were given artificial tears and fumigation treatment of traditional Chinese(Four Yellow Qing Ling Water)once a day. After treatment for 14d, the Schirmer Ⅰ test(SⅠt), break-up time(BUT), cornea fluorescein staining(FL)and clinical efficacy of two groups were compared.

RESULTS: The efficiency rate of observation group was significantly better than the control group(87.8% vs 70.7%, P<0.5). The SⅠt and BUT in the observation group were significantly higher than those in the control group(8.43±2.51mm/5min vs 6.38±2.52mm/5min, P<0.05; 8.60±2.47s vs 6.35±2.29s, P<0.05); the FL in the observation group(0.84±0.75 vs 1.26±0.84, P<0.05)significantly lower than those in the control group.

CONCLUSION: The fumigation treatment of traditional Chinese medicine(Four Yellow Qing Ling Water)combined with artificial tears for dry eyes can improve the clinical symptoms of dry eye syndrome.