目的：采用光学相干断层扫描增强深部成像(enhanced depth imaging optical coherence tomography，EDI-OCT)技术观察和比较不同程度妊娠高血压疾病(pregnancy-induced hypertension syndrome，PIH)眼底病变患者黄斑区视网膜和脉络膜厚度的变化。

方法：对确诊为PIH的孕产妇150例289眼进行散瞳眼底检查和黄斑EDI-OCT检查，并根据Duke-Elder分期标准对患者进行分组P1(血管痉挛期组)、P2(血管硬化期组)、P3(视网膜病变期组)，以眼底正常患者作为对照组P0(眼底正常组)，分别对每组患者的黄斑区各象限视网膜神经纤维层(retinal nerve fiber layer，RNFL)厚度、中心凹处视网膜厚度和脉络膜厚度分别进行测量。

结果：本研究150例289眼妊娠高血压疾病患者中，眼底正常者36例72眼(24.9%)，有眼底病变者114例217眼(75.1%)。不同程度眼底病变的PIH患者视网膜和脉络膜厚度有不同改变。血管硬化期组黄斑中央区(central subfield，CSF)、中心凹视网膜厚度和脉络膜厚度均低于眼底正常组，差异有统计学意义(P<0.05)。视网膜病变期组黄斑区各象限神经纤维层(retinal nerve fiber layer，RNFL)厚度、中心凹视网膜厚度和脉络膜厚度均显著高于其他三组，差异有统计学意义(P<0.05)。

结论：EDI-OCT是研究PIH相关眼底病变的重要工具之一，借助EDI-OCT观察和分析PIH眼底病变患者黄斑区视网膜和脉络膜厚度的改变，对深入研究 PIH所引起的视网膜和脉络膜局部微循环的病理性改变具有重要意义。

METHODS: Totally 150 patients(289 eyes)diagnosed with pregnancy-induced hypertension were identified by fundus examination and EDI-OCT after mydriasis. The patients were divided into four groups for the Duke-Elder class: P1(vasospasm), P2(angiosclerosis), P3(retinopathy), and control group P0(normal fundus). The average retinal nerve fiber layer thickness in each quadrant, foveal retinal and choroidal thickness were measured by EDI-OCT respectively.

RESULTS: There were 36(72 eyes, 24.9%)of 150 women with pregnancy-induced hypertension had no retinal changes, and 114(217 eyes, 75.1%)of 150 cases identified by clinical examinations as having retinal findings. The retinal and choroidal thickness varied with different stages of fundus changes. The RNFL thickness of central subfield(CSF), the foveal retina and choroid were significantly higher in angiosclerosis stage than that in normal fundus group(P<0.05). The RNFL from each area, the foveal retina and choroid were all thicker in retinopathy stage than the other three groups(P<0.05).

CONCLUSION: EDI-OCT is one important tool for the study of fundus changes in PIH. Findings in the morphology changes of retina and choroid with the help of EDI-OCT may indicate more about retinal microcirculation changes caused by pregnancy-induced hypertension in depth.