目的：运用Meta分析方法系统评价近5a来中医药治疗干眼的疗效。

方法：按Cochrane系统评价方法，计算机检索Medline(2013-01/2017-10)、EMbase(2013/2017年)、Cochrane图书馆(2017年)、万方数据库(2013/2017年)、维普数据库(2013/2017年)、中国知网数据库(2013/2017年)，纳入近5a中医药治疗干眼的随机对照研究，使用RevMan5.0统计软件进行资料提取与Meta分析。

结果：共纳入10个随机对照研究，其中1篇为英文文献，9篇为中文文献，共包括1 229眼。其中9个研究在疗程结束后进行了BUT的测定，结果显示差异有统计学意义(P<0.00001)； 9个研究在疗程结束后进行了泪液流量的测定，结果显示差异有统计学意义(P<0.0001)； 2个研究在疗程结束后进行了FL的测定，结果显示差异无统计学意义(P=0.25)； 3个研究在疗程结束后进行了干眼症状的测定，结果显示差异有统计学意义(P=0.0003)； 总体疗效比较，两组差异有统计学意义(P<0.00001)。

结论：中医药治疗能显著延长患者泪膜破裂时间(break-up time，BUT)和增加泪液流量，在治疗干眼总体疗效上更有优势。

METHODS: According to the Cochrane evaluation system method, we searched Medline(January 2013 to October 2017), EMbase(2013-2017), Cochrane Library(2017), Wanfang database(2013-2017), VIP(2013-2017), and CNKI(2013-2017)for studies published. We included randomized controlled trials conducted the TCM in the treatment of dry eye. RevMan 5.0 statistical software data extraction and Meta analysis were conducted.

RESULTS: A total of 10 studies were identified, nine were from Chinese literature and one was from English literature, of which including 1 229 eyes. Nine of these studies performed BUT measurements at the end of the course of treatment. The results showed a statistically significant difference(P<0.00001). Nine studies performed tear flow measurements at the end of the course of treatment and the results showed a statistically significant difference(P<0.0001). Two studies performed FL measurements after the end of the course of treatment; the results showed no statistically significant difference(P=0.25). Three studies performed dry eye symptoms after the end of the course of treatment; the results showed that the differences were statistically significant(P=0.0003); the overall efficacy comparison, the difference between the two groups was statistically significant(P<0.00001).

CONCLUSION: TCM treatment can significantly prolong BUT and increase tear flow, and has more advantages in the treatment of dry eye.