目的：探讨拉坦前列素治疗开角型青光眼的疗效。

方法：选择2015-08/2017-08期间在我院就诊的开角型青光眼患者100例作为研究对象，根据治疗方法的不同分为观察组和对照组，各50眼。对照组采用噻吗洛尔滴眼液治疗，2次/d，每次1滴，连续治疗12wk； 观察组采用拉坦前列素滴眼液治疗，1次/d，每次1滴，连续治疗12wk。比较两组患者治疗前后眼压、眼部血流动力学指标、视野缺损度及不良反应发生情况。

结果：治疗前两组患者眼压水平相比，差异无统计学意义(P>0.05)； 治疗4、8、12wk后观察组眼压均低于对照组，差异均有统计学意义(P<0.05)。对照组治疗前后视网膜中央动脉(CRA)、睫状后短动脉(PCA)血流动力学指标相比，差异均无统计学意义(P>0.05)； 观察组CRA、PCA的舒张末期血流速度(EDV)与收缩期血流速度(PSV)均较治疗前显著升高，而血管阻力指数(RI)明显下降，差异均有统计学意义(P<0.05)。治疗前两组各方位视野缺损程度相比，差异无统计学意义(P>0.05)； 治疗后两组各方位缺损范围均明显缩小，且观察组患者视野缺损程度明显小于对照组，差异均有统计学意义(P<0.05)。两组患者不良反应发生率相比，差异无统计学意义(P>0.05)。

结论：开角型青光眼采用拉坦前列素滴眼液治疗效果显著，能够明显降低眼压，改善眼部血流动力学，缩小视野受损范围，具有良好的安全性。

METHODS: Totally 100 patients with open angle glaucoma who had been seeking treatment in our hospital between August 2015 and August 2017 were selected as the research subjects. These patients were divided into an observation group and a control group according to the random table method, with 50 cases in each group. The control group was treated with timolol maleate eye drops, 1 drop per time, 2 times a day, treated consecutively for 12wk. The observation group was given latanoprost eye drops for treatment, 1 drop per time, 1 time a day, for a continuous treatment of 12wk. The IOP, ocular hemodynamics, visual field defects and adverse reactions in the two groups were compared.

RESULTS: Before treatment, there was no statistically significant difference found on the intraocular pressure between the two groups(P>0.05); at 4, 8, 12wk after the treatment, the intraocular pressure at different time points in the observation group was shown to be lower than that in the control group, where the difference was statistically significant(P<0.05). There was no statistically significant difference shown in the artery hemodynamics indexes of CRA and PCA before and after treatment in the control group(P>0.05); the indicators of EDV and PSV of CRA, PCA indicators in the observation group significantly increased, while the RI index decreased significantly, with the difference being statistically significant(P<0.05). Before treatment, there was no statistically significant difference in all of the visual field defects between the two groups before treatment(P>0.05); after treatment, however, the scope of visual field defects was shrunk in both groups, with changes in the observation group more significant than the control group, and the difference was statistically significant(P<0.05)There was no statistically significant difference registered in the incidence of adverse reactions between the two groups(P>0.05).

CONCLUSION: For patients with open angle glaucoma, latanoprost eye drops is with significant curative effects and of relatively high value, which can significantly reduce the intraocular pressure, improve the ocular hemodynamics, and reduce the scope of eye damage with high safety.