[关键词]
[摘要]
糖尿病视网膜病变(diabetic retinopathy，DR)是糖尿病的微血管和神经并发症，氧化应激是其重要致病机制。自噬是细胞在生理和病理条件下的一种重要调节活动，能够通过降解细胞内多余或损伤的蛋白质和细胞器维持细胞内环境稳态。研究表明，自噬和氧化应激之间具有重要联系，本文从DR早期微血管病变、DR神经病变和DR其它病变等方面综述自噬与氧化应激的具体关系，以期为阐明DR发病机制提供新的思路。
[Key word]
[Abstract]
Diabetic retinopathy(DR)is a microvascular and neurological complication of diabetes mellitus. Oxidative stress is an important pathogenic mechanism for the occurrence of DR. Autophagy is a crucial regulatory mechanism of cells under both physiologic and pathologic conditions. It can maintain intracellular homeostasis by degrading redundant or damaged proteins and organelles in cells. Prior studies have documented that there is a strong connection between autophagy and oxidative stress of DR. This article reviewed previous findings regarding the specific relationship between autophagy and oxidative stress in DR, including early microvascular lesions, neuropathy and other pathological changes. The aim of this review is to provide new ideas to clarify the pathogenesis of DR.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.81060077); 2014年度云南省医疗卫生单位内设研究机构科研项目(No.2014NS183)
