目的：了解南充市顺庆区50岁及以上人群年龄相关性黄斑变性(AMD)患病率并探讨影响AMD的相关因素。

方法：以人群为基础的流行病学调查。2013-05/10，采用分层整群随机抽样方法，抽取四川省南充市顺庆区50岁及以上人群共2 242人。调查内容包括一般信息登记，体格检查，实验室检查，眼科检查。AMD的诊断标准采用AMD国际临床分级系统。采用SPSS 13.0统计学软件对结果进行分析。

结果：本研究调查实际有2 097人接受全程检查，受检率为93.53%。检出AMD患者207例(283眼)，总患病率为9.87%，标准化后AMD的患病率为9.73%。早期和晚期AMD患病率分别为9.25%和0.62%，其中渗出性AMD患病率为0.14%。50～59、60～69、70～79及≥80岁组的AMD患病率分别为6.38%、9.27%、14.69%、17.39%。AMD导致双侧盲及低视力患病率分别为0.48%和1.45%。晚期AMD患眼视力明显低于早期AMD患眼视力。与AMD相关的影响因素有8个，年龄、收缩压、吸烟、阳光暴露、糖尿病史、白内障手术、血清总胆固醇是AMD发生的危险因素，受教育程度是保护因素。

结论：南充市顺庆区50岁及以上人群AMD患病率为9.87%，AMD患病率随着年龄的增加呈明显增长的趋势； 晚期AMD严重影响视力； AMD致病危险因素包括年龄、收缩压、吸烟、阳光暴露、糖尿病史、白内障手术、血清总胆固醇，保护因素为受教育程度。

METHODS:Population-based cross-sectional of epidemiological investigation. Persons aged 50 years and older, recruited between May to October 2013, from Shunqing District of Nanchong, Sichuan province, China. Totally 2242 eligible residents who aged 50 years and older were selected using a stratified, clustered, and random sampling technique. All participants underwent a standardized interview concerning general data, physical examinations, laboratory examinations, and comprehensive eye examinations. The diagnostic criteria was followed the international clinical classification systems. The survey data were analyzed by statistical software SPSS 13.0.

RESULTS: Totally 2242 participates, whole examination were finished for 2097 persons, with the examination rate of 93.53%. There were 207 patients(283 eyes)were diagnosed as AMD, with the total prevalence rates of 9.87% and the standardized prevalence rates of 9.73%. Early and late AMD prevalence rates were 9.25% and 0.62%, respectively, among participants, in which the prevalence of exudative AMD were 0.14%. The prevalences of AMD in the age groups of 50-59, 60-69, 70-79 and no less than 80 years were 6.38%, 9.27%, 14.69% and 17.39%, respectively. The visual acuity of late AMD was significantly worse than early AMD. The prevalence of bilateral blindness and low vision were 0.48% and 1.45% of the AMD patients. There were eight factors associated with AMD: age, systolic blood pressure, smoking, sun exposure, history of diabetes, cataract surgery and serum total cholesterol were the risk factors of AMD, while the level of education was a protective factor.

CONCLUSION: The prevalence of AMD in Shunqing District of Nanchong was 9.87%. With the age increasing, the prevalence rate of AMD was significantly increased. The late AMD affected vision seriously. The risk factors of AMD included age, systolic blood pressure, smoking, sun exposure, history of diabetes, cataract surgery and serum total cholesterol, and the protective factor was the level of education.