目的：观察糖尿病视网膜病变患者外周血趋化因子巨噬细胞炎症蛋白-1α(macrophage inflammatory protein，MIP-1α)、MIP-1β水平变化，并分析其临床意义。

方法：选取佛山市第五人民医院和佛山市南海区第四人民医院收治的糖尿病无视网膜病变患者(DM组)、非增殖期糖尿病视网膜病变患者(NPDR组)和增殖期糖尿病视网膜病变患者(PDR组)，各50例； 选取50例健康体检者作为对照组。观察不同组别患者外周血趋化因子MIP-1α、MIP-1β水平、血糖情况和细胞因子水平的差异，采用Pearson相关分析法分析糖尿病视网膜病变患者外周血趋化因子MIP-1α、MIP-1β水平与血糖和细胞因子水平的相关性。

结果：DM组患者的MIP-1α、MIP-1β和平均血糖(mean blood glucose，MBG)水平均高于对照组，差异有统计学意义(t=6.306、2.954、3.617，均P<0.05)； DM组患者的胰岛素样生长因子-1(insulin like growth factor-1，IGF-1)、成纤维细胞生长因子-21(fibroblast growth factor-21，FGF-21)、血管内皮生长因子(VEGF)水平均高于对照组，差异有统计学意义(t=27.216、7.778、3.214，均P<0.05)。PDR组患者的MIP-1α、MIP-1β和MBG水平均高于NPDR组，差异有统计学意义(t=6.620、3.461、3.378，均P<0.05)； PDR组患者的IGF-1、FGF-21、VEGF水平高于NPDR组，差异有统计学意义(t=10.260、12.611、4.108，均P<0.05)。糖尿病视网膜病变患者的MIP-1α、MIP-1β水平与MBG、IGF-1、FGF-21、VEGF水平呈正相关。

结论：增殖期糖尿病视网膜病变患者的MIP-1α、MIP-1β水平较高，且与血糖和细胞因子水平呈正相关。

METHODS: The patients with diabetic retinopathy(DM group), monproli fertive diabetic retinopathy(NPDR group)and proliferative diabetic retinopathy(PDR group)were selected in Foshan Fifth People's Hospital and the Fourth People's Hospital of Nanhai District, Foshan. There were 50 patients were treated in each group, and 50 healthy persons(control group)were selected for the same period. The differences in the levels of chemokine MIP-1 alpha, MIP-1 beta, blood glucose and cytokines in peripheral blood of patients with different groups were observed. The correlation between the levels of chemokine MIP-1α and MIP-1β of peripheral blood in patients with diabetic retinopathy and the level of blood glucose and cytokines was analyzed by Pearson correlation analysis.

RESULTS: The levels of MIP-1α, MIP-1β and mean blood glucose(MBG)in the DM group were higher than those in the control group(t=6.306, 2.954, 3.617; P<0.05). The levels of insulin like growth factor-1(IGF-1), fibroblast growth factor-21(FGF-21)and vascular endothelial growth factor(VEGF)in DM group were higher than those in control group(t=27.216, 7.778, 3.214; P<0.05). The levels of MIP-1α, MIP-1β and MBG in PDR group were higher than those in NPDR group(t=6.620, 3.461, 3.378; P<0.05). The levels of IGF-1, FGF-21 and VEGF in PDR group were higher than those in NPDR group(t=10.260, 12.611, 4.108; P<0.05). The level of MIP-1α and MIP-1β in patients with diabetic retinopathy is positively correlated with the levels of MBG, IGF-1, FGF-21 and VEGF.

CONCLUSION: The levels of MIP-1α and MIP-1β in patients with PDR are relatively high, and are positively correlated with blood glucose and cytokines levels.