[关键词]
[摘要]
角膜移植术是治疗终末期角膜疾病的常用方式，虽然角膜移植的成功率较其它器官移植高，但是术后排斥仍然是手术失败的主要原因。器官移植后排斥反应高度依赖于免疫细胞向淋巴组织或炎症部位的定向迁移和归巢，并受粘附分子和趋化因子的调控。调节性T细胞在免疫调节中起着关键性作用，通过诱导免疫耐受维持内环境稳定，在器官移植排斥反应、自身免疫性疾病及肿瘤相关研究中发挥重要作用。本篇综述主要介绍调节性T细胞参与眼部免疫耐受的相关研究，着重阐述调节性T细胞在角膜移植排斥过程中的作用、机制和应用。
[Key word]
[Abstract]
Keratoplasty is routinely used to treat end-stage corneal diseases. However, immune-mediated graft rejection remains the major cause of surgical failure. Organ transplant rejection is often due to the directional migration and homing of inflammatory cells to lymphoid tissues and local inflammatory sites, which is regulated by various adhesion molecules and chemokines. Regulatory T cells play a key role in immune regulation and are essential for maintaining peripheral tolerance. Recent studies have revealed that regulatory T cells play important roles in preventing organ transplant rejection and the development of autoimmune diseases. This review will summarize the recent research on the induction of ocular immune privilege by regulatory T cells, with special focus on how regulatory T cells mediate tolerance in the eye and clinical potential of modulating these mechanisms during corneal transplantation.
[中图分类号]
[基金项目]
国家自然科学基金重点项目(No.81530027); 国家自然基金面上项目(No.81471554); 山东省重点研发计划项目(No.2015GGH318010); 深圳市科技计划项目(No.JCYJ20170413165432016,JCYJ20160531185449995); 深圳市海外高层次人才创新创业专项(孔雀技术创新)(No.KQJSCX20160301140901)
