[关键词]
[摘要]
抗血管内皮生长因子(vascular endothelial growth factor，VEGF)药物对于治疗视网膜疾病，比如渗出性年龄相关性黄斑变性、糖尿病视网膜病变(diabetic retinopathy，DR)、视网膜静脉阻塞具有革命性意义。玻璃体腔内注射抗VEGF药物后能明显减轻黄斑水肿，但同时是否也会破坏视网膜微循环、加快视网膜毛细血管闭塞？本文通过相干光断层扫描血流成像(optical coherence tomography angiography，OCTA)和超广角眼底血管造影(ultra-widefield fluorescein angiography，UWFA)技术观察糖尿病性黄斑水肿(diabetic macular edema，DME)患者抗VEGF治疗对视网膜毛细血管的影响，从黄斑无血管区面积、无灌注区大小及血流密度三方面进行综述。
[Key word]
[Abstract]
Anti-vascular endothelial growth factor(VEGF)agents are revolutionary in the treatment of retinal diseases, such as exudative age-related macular degeneration,diabetic retinopathy(DR), and retinal vein occlusion. Intravitreal injection of anti-VEGF agents can reduce macular edema significantly, but whether anti-VEGF therapy impairs retinal microcirculation and facilitates retinal vascular occlusion. This article reviews on the effect of anti-VEGF therapy on retinal capillary in diabetic macular edema, from three aspects of foveal avascular zones, areas of nonperfusion and retinal capillary density, using optical coherence tomography angiography(OCTA)and ultra-wide field fluorescein angiography(UWFA).
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