目的：探讨分析糖尿病视网膜病变(diabetic retinopathy，DR)患者全视网膜激光光凝术(panretinal photocoagulation，PRP)治疗后1a视网膜神经纤维层(retinal nerve fiber layer，RNFL)厚度的变化。

方法：选取2014-05/2017-06在我院行PRP治疗的92例92眼DR患者，采用OCT的DISC CIRCLE程序，测量分析以视盘为中心、直径3.45mm范围DR患者PRP术前和术后1a(采用Follow-Up程序自动追踪模式)视盘周围RNFL厚度，按视盘上方(S)、下方(I)、鼻侧(N)、颞侧(T)4个象限分区所得的数值进行统计分析。

结果：DR患者PRP术后1a较术前视盘周围上方、下方、鼻侧、颞侧和全周平均RNFL厚度明显变薄，且差异有统计学意义(均P<0.05)。

结论：PRP治疗可导致视网膜RNFL变薄，临床上应充分重视和考虑RNFL的损伤，更好地保护视网膜神经细胞的机能对DR治疗具有重要意义。

METHODS: A total of 92 patients(92 eyes)with DR who underwent PRP in our hospital from May 2014 to June 2017 were enrolled. The DISC CIRCLE procedure of OCT was used to measure the preoperative and one-year postoperative RNFL of patients with DR in the range of 3.45mm diameter around the optic disc, using Follow-Up program automatic tracking mode. The statistical analysis was conducted according to the values obtained in the four quadrant(superior, nasal, temple and inferior).

RESULTS: The average RNFL thickness around optic disc of the patients with DR after 1a of PRP was significantly thinner than the preoperative, the difference was statistically significant(P<0.05).

CONCLUSION: PRP treatment can lead to thinning of RNFL in the retina, which should given full attention and consideration the damage of RNFL in clinical practice. The function of protecting retinal nerve cells is of great significance for DR treatment.