目的：探讨自体血清联合重组人表皮生长因子对角膜异物剔除术后角膜创面的修复效果。

方法：选取2015-10/2016-03于我院行角膜异物剔除手术的患者92例110眼，随机分为治疗组和对照组，术后对照组患者使用重组人表皮生长因子滴眼液点眼，治疗组患者在对照组的基础上联合使用自体血清滴眼。手术前后，采用AS-OCT观察角膜创面情况。术后评估两组患者的临床疗效及泪液中TNF-α和IL-6的浓度。

结果：术后1wk治疗组患者治愈率(96.4% vs 78.2%)和术后2d角膜荧光素染色阴性率(98.2% vs 83.6%)均明显高于对照组，泪液中TNF-α和IL-6(51.47±7.83、5.29±1.67ng/L)浓度均明显低于对照组(143.62±18.12、13.95±3.44ng/L)。术后治疗组患者角膜上皮愈合时间(1.4±0.6d)较对照组(2.2±1.3d)明显缩短。术后1wk，AS-OCT图像显示治疗组修复后的角膜基质形态更加接近术前正常水平。

结论：自体血清联合重组人表皮生长因子对角膜异物剔除术后角膜创面的修复效果显著，可以明显缩短角膜创面愈合时间，减轻炎症反应，对角膜基质具有良好的修复功能。

METHODS: Totally 92 patients with corneal foreign body(110 affected eyes)as the research object in our hospital from October 2015 to March 2016. All the patients were divided into the treatment group and the control group according to the random number table. There was no significant difference between the two groups in age, sex and disease course. Both groups received corneal foreign body elimination by slit lamp. The treatment group was given eye drops containing epidermal growth factor combined autologous serum and tobramycin after surgery, while the control group was only administrated with epidermal growth factor and tobramycin. Treatment effects were compared 1wk after treatment.

RESULTS: One week after the treatment, the cure rate in the treatment group(96.4%)was much higher than that in the control group(78.2%). Two days after treatment, the fluorescein staining in the treatment group was 98.2%, it was higher than that in the control group(83.6%). The concentration of TNF-α and IL-6 of the treatment group was lower than that in the control group. One week after the treatment, AS-OCT images showed that the repair of corneal matrix in the treatment group was closer to the preoperative normal level.

CONCLUSION: The treatment effect that AS combined rhEGF is much better than that only usde rhEGF, shortened healing time of corneal epithelial wound. It is more effective and security to treat traumatic corneal epithelial defect, better repair function to corneal matrix.