目的：分析影响角膜塑形镜定位的相关因素。

方法：前瞻性研究。选取2014-07/2016-12于我院配戴角膜塑形镜的近视患者88例88眼，评估戴镜后1mo角膜塑形镜定位情况，并分析角膜塑形镜偏位程度与戴镜前年龄、等效球镜度、角膜散光、e值、角膜陡峭曲率和平坦曲率、角膜前表面曲率不对称指数的关系。

结果：根据本课题组制定的角膜塑形镜定位分级方法，戴镜后1mo本组患者中Ⅰ级者24眼，Ⅱ级者26眼，Ⅲ级者25眼，Ⅳ级者13眼。不同分级患者戴镜前等效球镜度、角膜陡峭曲率和平坦曲率均有差异(P<0.05)。多元线性回归分析显示，角膜塑形镜偏位程度与戴镜前等效球镜度呈负相关(P<0.01)，与其它因素相关性较弱。

结论：戴镜前等效球镜可能是影响角膜塑形镜偏中心定位的主要因素。

METHODS: Within a prospective study, 88 eyes of 88 patients who visited to our center between July 2014 and December 2016 were enrolled. To verify the possible role of the spherical equivalent(SE), the corneal astigmatism(CA), e value, steep K, flat K, front curvature asymmetry index(SIf)and age in the ortho-K location prediction.

RESULTS: This study included 24 eyes of grade Ⅰ decentration, 26 eyes with grade Ⅱ, 25 eyes with grade Ⅲ, and 13 eyes with grade Ⅳ, by which based on the decentration system that published by our team. One-way ANOVA showed that there was statically significant difference of SE, Ks and Kf in different grading groups(P<0.05). Multiple linear regression analysis showed SE was negatively correlated with the decentration(P<0.01). The others factors such as the CA, e, Ks, Kf, SIf, age has weak correlation with the ortho-K decentration.

CONCLUSION: The SE might be the main factor which lead to the ortho-K decentration.