目的：评估糖尿病和非糖尿病患者白内障超声乳化术后脉络膜厚度(SFCT)和黄斑厚度(CMT)的变化。

方法：前瞻性研究。包括53例轻度或中度非增殖性糖尿病视网膜病变(NPDR)无黄斑水肿患者和53例行白内障超声乳化术非糖尿病患者。术前、术后1mo和3mo用EDI-OCT测量脉络膜厚度和黄斑厚度，并比较两组的SFCT和CMT变化。

结果：糖尿病患者中，基线处CMT为267±32 μm。术后CMT显著升高，术后1mo为291±77 μm(P=0.034)，术后3mo为293±75 μm(P=0.047)。基线处SFCT为199±72 μm。术后SFCT显著升高，术后1mo为231±73 μm(P=0.035)，术后3mo为248±91 μm(P=0.026)。在非糖尿病患者中，基线处CMT为264±29 μm。术后显著CMT升高，术后1mo为278±42 μm(P<0.001)，术后3mo为276±56 μm(P=0.028)。基线处SFCT为236±60 μm。术后SFCT显著提高，术后1mo为265±64 μm(P<0.001)，术后3mo为240±60 μm(P=0.234)。两组间CMT的变化无统计学差异(均P>0.05)。尽管非糖尿病组患者的基线脉络膜较厚，但研究组术后1mo(P=0.97)和术后3mo(P=0.97)的SFCT变化无显著差异。

结论：术后两组间CMT和SFCT均显著提高。CMT和SFCT变化在糖尿病和非糖尿病患者间无显著不同。

METHODS: In this prospective study, 53 patients with mild or moderate non-proliferative diabetic retinopathy(NPDR)without macular edema and 53 non-diabetic patients underwent uneventful phacoemulsification cataract surgery. Subfoveal choroidal thickness and central macular thickness were measured before and one month and three months after the surgery using enhanced depth imaging optical coherence tomography(EDI-OCT)and the changes of SFCT and CMT were compared between the two study groups.

RESULTS: In diabetic cases, the mean CMT at the baseline was 267±32 μm. The CMT significantly increased after surgery with a mean value of 291±77 μm at 1mo(P=0.034)and 293±75 μm at 3mo(P=0.047). The mean SFCT at the baseline was 199±72 μm. The SFCT significantly increased after surgery with a mean value of 231±73 μm at 1mo(P=0.035)and 248±91 μm at 3mo(P=0.026). In non-diabetic cases, the mean CMT at the baseline was 264±29 μm. The CMT significantly increased after surgery with a mean value of 278±42 μm at 1mo(P<0.001)and 276±56 μm at 3mo(P=0.028). The mean SFCT at the baseline was 236±60 μm. The SFCT significantly increased after surgery with a mean value of 265±64 μm at 1mo(P<0.001)and 240±60 μm at 3mo(P=0.234). The changes of CMT were not significantly different between the study groups(all P>0.05). Although the non-diabetic cases had thicker choroid at the baseline, the change of SFCT was not significantly different between study groups 1mo postoperative(P=0.97)and was borderline 3mo after surgery(P=0.05).

CONCLUSION: CMT and SFCT significantly increased post operatively in both groups. The changes of CMT and SFCT were not significantly different between diabetic and non-diabetic cases.