目的：比较右美托咪定与苯巴比妥钠在白内障围手术期的临床疗效和安全性。

方法：前瞻性研究。选取120例拟在表面麻醉下行白内障手术的患者。术前，患者分别接受鼻内喷注右美托咪定和肌肉注射苯巴比妥钠。观察术后视觉模拟评分(VAS)和爱荷华州麻醉满意量表(ISAS)，围手术期生命体征和眼内压，术中并发症和药物不良反应。

结果：与苯巴比妥钠组比较，右美托咪定组有较低的VAS评分和较高的ISAS评分、术中收缩压更稳定、能更好地降低术中眼内压，且有较低的并发症和药物不良反应发生率。

结论：与苯巴比妥钠比较，右美托咪定在白内障围手术期经鼻给药有较好的镇静和镇痛效果，能提高患者的满意度和增加手术的安全性。

METHODS: A prospective study. Selected 120 cases of patients underwent cataract surgery under topical anesthesia. Before surgery, patients were administed dexmedetomidine nasal spray and phenobarbital sodium intramuscularly, respectively. Observed postoperative Visual Analogue Scale(VAS), Iowa Satisfaction with Anesthesia Scale(ISAS), perioperative vital signs and intraocular pressure, intraoperative complications and adverse drug reactions.

RESULTS: Compared with the phenobarbital sodium group, the dexmedetomidine group had lower VAS score and higher ISAS score, more stable intraoperative systolic blood pressure, better reduction of intraoperative intraocular pressure, lower incidence of complications and adverse drug reactions.

CONCLUSION: Compared with phenobarbital sodium, the administration of dexmedetomidine nasal spray in the perioperative period of cataract surgery has beneficial sedative and analgesic effection, which can improve the satisfaction of patients and increase the safety of surgery.