目的：探究雷珠单抗联合玻璃体切割术治疗DR合并新生血管性青光眼(NVG)的临床效果。

方法：选取2016-01/2018-02我院眼科收治的DR合并NVG患者198例，根据治疗方案不同分为观察组(103例)和对照组(95例)，观察组采用术前注射雷珠单抗联合玻璃体切割术治疗，对照组单纯采用玻璃体切割术治疗，玻璃体切割术后10～15d Ⅱ期实施Ahmed房水引流阀植入。观察两组治疗后眼压、BCVA、VEGF等指标变化情况。

结果：观察组的玻璃体切割术的手术时间、新生血管出血次数、电凝次数均低于对照组(P<0.001)。观察组在玻璃体切割术后1wk和Ⅱ期Ahmed房水引流阀植入术后1mo BCVA、眼压均低于对照组(P<0.001)。观察组Ⅱ期Ahmed房水引流阀植入术前VEGF和术后1mo视网膜黄斑中心凹厚度均低于对照组(P<0.001)。观察组总并发发生率低于对照组(10.7% vs 28.4%，P<0.05)。

结论：雷珠单抗联合玻璃体切割术治疗DR合并NVG的疗效显著，且使Ⅱ期Ahmed房水引流阀植入手术难度下降，对患者视力、眼压水平恢复较好。

METHODS: Selected 198 patients from 2016-01 to 2018-02 DR merger NVG eye treated in our hospital according to the different treatments were divided into observation group(103 cases)and control group(95 cases). Preoperative observation group used by licensed joint resistance for the treatment of vitreous cut, for the treatment of the control group only with vitreous cut, vitreous cut after 10-15d Ⅱ period implementation Ahmed aqueous humor drainage valve implantation. The changes of intraocular pressure, BCVA and VEGF in the two groups after treatment were observed.

RESULTS: The time of vitrectomy, the number of neovascularization and electrocoagulation in the observation group were all lower than those in the control group(P<0.001). Observation group in the vitreous cut postoperative 1wk and Ⅱ Ahmed, a aqueous humor drainage valve implantation after 1mo BCVA, intraocular pressure was significantly lower than control group(P<0.001). Observation group stage Ⅱ Ahmed aqueous humor drainage valve implantation before VEGF and postoperative 1mo macular center thickness of the concave is lower than the control group(P<0.001). The total complication rate in the observation group was lower than that in the control group(10.7% vs 28.4%, P<0.05).

CONCLUSION: Licensed joint resistance for the treatment of vitreous cut DR merger NVG curative effect is distinct, and made them Ⅱ period Ahmed aqueous humor drainage valve implants difficulty falling, recovery of patients' visual acuity, intraocular pressure level is good.