[关键词]
[摘要]
视网膜色素上皮对维持光感受器及其他视网膜细胞的存活和正常生理功能具有重要意义，其病变可引起众多视网膜疾病的发生发展。近年来有研究表明，长链非编码RNA(LncRNA)在眼部相关疾病中存在差异表达，并对不同类型眼病的发生发展起调控作用。这提示LncRNA可以作为基因诊断和治疗眼科疾病的新靶点。视网膜色素上皮细胞对视网膜功能具有不可忽视的作用，若从LncRNA角度对其进行研究，将对视网膜疾病的诊断与治疗开辟新的道路。
[Key word]
[Abstract]
Retinal pigment epithelium(RPE)plays an important role in maintaining the normal physiological function of photoreceptors and other retinal cells. The pathological changes of RPE can cause the occurrence and development of many retinal diseases. It was reported rencently that there are differential expressions of long noncoding RNAs(LncRNAs)in ophthalmic eye diseases, which play important roles in the pathogenesis of different types of eye diseases. It indicated that LncRNAs may be new targets for gene diagnosis and treatment of ocular diseases. RPE cell is important for retinal function. It will find a novel way for the diagnosis and treatment of retinal diseases if we investigate RPE from the perspective of LncRNA.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81470633)
