[关键词]
[摘要]
目前，近视已成为一种全球性公共卫生疾病，其发生多是由遗传和环境等因素引起。单核苷酸多态性(SNPs)是指在基因组水平上发生的、由单个碱基的改变引起的脱氧核糖核酸(DNA)序列多态性。近年来有文献报道，相关基因位点上的SNPs的变化与近视的发生发展密切相关。本文就近视相关基因的SNPs与近视发生发展的关联研究现状作一综述，以期为近视病因和病理机制的研究提供新的思路。
[Key word]
[Abstract]
At present, myopia has become a public health disease worldwide, and its occurrence is mostly caused by genetic and environmental factors. Single nucleotide polymorphisms(SNPs)are the changes in single base at the genomic level caused by DNA sequence polymorphisms. In recent years, it is reported that the change of SNPs in myopic related gene loci is closely related to the occurrence and development of myopia. The present paper reviewed the current status of the association between SNPs of myopia-related genes and the development of myopia, providing a new insight into the future research of pathogenesis of myopia.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.81603421); 山东省重点研发计划(No.2019GSF108252,2017CXGC1211)
