目的：探究先天性白内障患者的AL和角膜曲率，为该疾病的发展、治疗和预后提供重要参考。

方法：回顾分析2014-01/2018-12在我院确诊为先天性白内障并住院手术，排除其他眼部或全身疾病的20岁以内的患者229例333眼。使用IOL Master500测量患者的眼轴和角膜曲率，角膜曲率使用K1与K2的平均值Km来表示。采用偏相关分析对AL、Km与年龄的关系进行评估，与年龄相关的参数使用逐步多元回归进行曲线拟合。比较双眼患者、单眼患者患眼及健眼的AL和Km差异，并对比男性与女性患者AL和Km的不同。

结果：患者的AL与年龄呈正相关(r=0.250，P=0.001)，得到AL=20.85+0.96×ln(年龄)的拟合曲线，而患者的Km与年龄无相关性(r=-0.024，P=0.759)。男性和女性患者的AL无明显差异(P=0.495)，但女性患者的Km大于男性患者(P=0.018)。双眼患者的AL与单眼患者患眼的AL无差异(P=0.159)，但小于单眼患者健眼的AL(P=0.033)。双眼患者的Km与单眼患者患眼、健眼的Km均无差异(P=0.483、0.176)。

结论：先天性白内障可影响AL发育，尤其对于双眼患者，其AL小于单眼患者健眼的AL； 尚未发现对角膜曲率的影响，但女性患者的角膜曲率大于男性患者。

METHODS: From January 2014 to December 2018, 229 patients(333 eyes)with congenital cataract aged less than 20 years old before surgery and without other ocular diseases or systemic diseases were included in the retrospective study. Their AL and corneal curvature were measured using IOL Master 500. Corneal curvature was represented by Km, which was the mean of K1 and K2.The data were statistically analyzed using partial correlation analysis, to detect the correlation between patients' AL, Km and age, and we conducted curve fitting for the correlated parameters and age. We compared bilateral and unilateral cataract's AL and Km, and we also compared male and female patients' AL and Km.

RESULTS: The correlation between patients' AL and age was significant(r =0.250, P=0.001), and the fitting curve was obtained with equation AL=20.85+0.96×ln(age), but patients' Km wasn't significantly correlated with age(r= -0.024, P=0.759). No significant difference was found in AL between male and female patients(P=0.495), but Km was significantly greater in female patients than that in male patients(P=0.018). AL wasn't significantly different between eyes from bilateral cataract and affected eyes from unilateral cataract(P=0.159), but AL was significantly shorter in bilateral cataract than that in healthy eyes from unilateral cataract(P=0.033). No significant difference was found in Km between eyes from bilateral cataract and affected eyes or healthy eyes from unilateral cataracts(P=0.483, 0.176).

CONCLUSION: Congenital cataract may affect AL growth, especially in bilateral cataract, AL was shorter in bilateral cataract than that in healthy eyes from unilateral cataract. No effect of congenital cataract was found on corneal curvature, but corneal curvature was significantly greater in female patients than that in male patients.