目的：回顾性研究丹参川芎嗪在非动脉炎性前部缺血性视神经病变(NAION)中的疗效及作用机制。

方法：随机选取NAION患者60例，对照组(30例)给予口服醋酸泼尼松片加颞浅动脉旁皮下注射复方樟柳碱注射液治疗； 试验组(30例)加用丹参川芎嗪注射液治疗，疗程14d。采用ELISA检测两组患者血浆中IL-1β和TNF-α水平，采用Western blot检测两组患者血浆中Bcl-2和Caspase-3蛋白表达水平。

结果：两组患者最佳矫正视力均有提高； 试验组患者治疗后血浆中IL-1β和TNF-α水平均比对照组降低(P<0.05)； 试验组患者血浆Bcl-2、Caspase-3的表达与治疗前相比有差异(P<0.05)，且两组间两个蛋白表达有统计学差异(P<0.05)。

结论：丹参川芎嗪通过降低体内的炎性水平，抑制细胞凋亡，促进视功能的恢复。

METHODS: A total of 60 cases of non-arteriti anterior ischemic optic neuropathy were randomly divided into two groups. The control group(n=30 cases)was treated with oral prednisone acetate tablets and injection of compound anisodine. The experimental group(n=30 cases)was the same to the control group and added intravenous salvia ligustrazine, the period of treatment was 14d. The levels of IL-1β and TNF-α were detected by ELISA, and the protein expression levels of Bcl-2 and Caspase-3 were detected by Western blot.

RESULTS: The best corrected visual acuity was improved in both groups. The plasma levels of IL-1β and TNF-α were significantly lowed in the experimental group than the control group, and the difference between the two groups was statistically significant(P<0.05). The protein expression of Bcl-2 and Caspase-3 in the two groups were different from those before treatment(P<0.05), and the difference between the two groups was statistically significant(P<0.05).

CONCLUSION: Salvia ligustrazine promotes the recovery of visual function by reducing the level of inflammation and inhibiting cell apoptosis in body.