目的：探讨睡眠呼吸暂停低通气综合征(SAHS)及夜间低血压(NHP)与非动脉炎性前部缺血性视神经病变(NAION)发病的相关性。

方法：回顾性分析2016-10/2018-12我院就诊的NAION患者，其中NAION组31例，对照组31例为健康体检者。对NAION患者和对照组行24h动态血压监测明确夜间血压情况，用Berlin调查问卷评估SAHS患病风险，用多导睡眠呼吸记录仪(Polysomnography)行夜间呼吸暂停低通气指数(AHI)、最小氧饱和度(MOS)监测。根据AHI对SAHS进行诊断和分级。

结果：NAION组有23例患者(74%)出现NHP，对照组中NHP患者为14例(45%)，NAION组中NHP的患病率显著高于对照组(P=0.020)。NAION组有22例(71%)伴有SAHS，而对照组SAHS患者为13例(42%)。Logistic回归分析显示，NHP(OR=2.762，95% CI：1.275～3.746)、AHI(OR=2.959，95% CI：1.478～6.432)及MOS(OR=3.058，95% CI：1.734～7.743)是NAION发生的危险因素。

结论：SAHS和NHP与NAION的发生密切相关，预防SAHS和NHP的发生与进展可能有助于防治NAION。

METHODS:The retrospective study participants included 31 patients with NAION and 31 age- and sex-matched controls. Twenty-four hour ambulatory blood pressure monitoring was used to evaluate the presence of NHP in NAION group and in control group. Berlin questionnaire was involved to evaluate the risk of SAHS. All participants underwent full-night respiratory polysomnography for monitoring apnea-hypopnea index(AHI), minimum oxygen saturation(MOS).

RESULTS: Totally 23 NAION patients(74%)presented with NHP, which was found in 14 control subjects(45%). The incidence of NHP was significantly higher among NAION patients compared to the controls(P=0.020). Of the 31 NAION patients, 22 patients(71%)had SAHS, compared to 13(42%)control subjects. Logistic regression analysis showed that NHP(OR=2.762, 95% CI: 1.275-3.746), AHI(OR=2.959, 95% CI: 1.478-6.432)and MOS(OR=3.058, 95% CI: 1.734-7.743)were risk factors for NAION.

CONCLUSION: SAHS and NHP were related with NAION. Taking precautions against SAHS and NHP may be crucial to the prevention and cure of NAION.