目的：探讨血清淀粉样蛋白A(SAA)在感染性眼内炎诊断中的临床应用价值。

方法：收集2016-06/2019-03我院就诊的270例患者，其中116例感染性眼内炎患者作为研究组，154例非感染性患者作为对照组。采用胶体金免疫层析法检测SAA水平，用受试者工作特征(ROC)曲线分析诊断效能。

结果：感染性眼内炎患者和对照组SAA值中位数分别为14.98、2.56mg/L，两组比较有差异(P<0.001)； CRP值和WBC值中位数两组比较均有差异(P<0.001)。SAA、CRP和WBC计数诊断感染性眼内炎的ROC曲线下面积分别为0.772、0.638、0.618，SAA检测取Youden指数最大值所对应的最佳临界值为6.975mg/L，其灵敏度为63.79%，特异度为84.42%。

结论：SAA联合CRP和WBC计数有助于提高感染性眼内炎的诊断效能。SAA可为感染性眼内炎的辅助诊断提供有用的参考信息。

METHODS:A total of 270 patients admitted to the Eye Hospital of Wenzhou Medical University from June 2016 to March 2019 were collected, including 116 patients with infectious endophthalmitis as the experimental group and 154 non-infectious patients as the control group. The levels of SAA was detected by colloidal gold immunochromatography. Variables were compared and diagnostic value was measured by using receiver operating characteristic(ROC)curve.

RESULTS:The median levels of SAA in experimental group and control group were 14.98mg/L and 2.56mg/L, respectively,the difference between the two groups was statistically significant(P<0.001); the median levels of CRP and WBC had statistic difference between two groups, respectively(P<0.001). The area under the ROC curve of SAA, CRP and WBC for diagnosis of infectious endophthalmitis were 0.772, 0.638 and 0.618 respectively. The optimal cut-off value corresponding to the maximum value of Youden index was 6.975mg/L by SAA, the sensitivity was 63.79% and the specificity was 84.42%.

CONCLUSION: SAA combined with CRP and WBC can improve the diagnostic efficacy of infective endophthalmitis. SAA can provide useful reference information for the assistant diagnosis of infectious endophthalmitis, which is worthy of clinical application.