目的：探讨复明片联合马来酸噻吗洛尔滴眼液治疗开角型青光眼的临床疗效。

方法：选择2017-04/2018-07于本院接受治疗的82例147眼开角型青光眼患者作为研究对象，根据治疗手段不同分为对照组41例72眼及观察组41例75眼。对照组予以马来酸噻吗洛尔滴眼液进行治疗，观察组在对照组基础上予以复明片治疗。观察两组患者临床疗效，对治疗前后眼压、血液流变学进行比较分析。

结果：治疗12wk后，观察组与对照组间的临床总有效率(94.7% vs 80.6%)比较有差异(P<0.05)； 两组患者眼压均明显低于治疗6wk后及治疗前(P<0.05)，且观察组眼压显著低于对照组(P<0.05)； 对照组PSV、EDV及RI与治疗前无差异(P>0.05)； 观察组PSV、EDV显著高于治疗前(P<0.05)，而RI显著低于治疗前(P<0.05)，且两组PSV、EDV及RI比较有差异(P<0.05)。两组患者总不良反应发生率比较无差异(P>0.05)。

结论：复明片联合马来酸噻吗洛尔滴眼液可有效改善患者的临床疗效，降眼压作用显著，同时对患者眼部血液流变学改善效果良好，安全可靠。

METHODS: Totally 82(147 eyes)patients with open angle glaucoma who were treated in our hospital from April 2017 to July 2018 were selected as the research objects. According to the treatment methods, they were divided into control group and observation group, 41 cases in each group. Patients in the control group(72 eyes)were treated with timolol lecitrate eye drops, while patients in the observation group(75 eyes)were treated with Fuming tablets on the basis of the control group. The clinical efficacy of the two groups was observed. The intraocular pressure and hemorheology of the patients in the two groups were compared and analyzed before and after treatment.

RESULTS: After 12wk treatment, there was a significant difference in the total clinical effective rate(94.7% vs 80.6%)between the observation group and the control group(P<0.05). And the intraocular pressure of both groups was significantly lower than that before and after 6wk of treatment(P<0.05), and the intraocular pressure of the observation group was significantly lower than that of the control group(P<0.05). The levels of PSV, EDV and RI in the control group were not significantly different from those before treatment(P>0.05); while the levels of PSV and EDV in the observation group were significantly higher than those before treatment(P<0.05), and the levels of RI were significantly lower than those before treatment(P<0.05). And there were significant differences in the levels of PSV, EDV and RI between two groups(P<0.05). There was no significant difference in the total incidence of adverse reactions between two groups during the treatment(P>0.05).

CONCLUSION:Fuming tablet combined with timolol maleate eye drops can effectively improve the clinical efficacy of patients with open angle glaucoma. The effect of lowering intraocular pressure is obvious. At the same time, it has a good effect on the ocular hemorheology of patients with open angle glaucoma. This is a safe and reliable clinical treatment of open angle glaucoma.