目的：探讨维生素D(Vit-D)缺乏与年龄相关性黄斑变性(ARMD)发生的相关性。

方法：选取2018-02/2019-02至运城市第一医院眼科门诊就诊及健康体检的423例45岁以上中老年人为研究对象，采用横断面调查研究方法，收集研究对象年龄、性别、ARMD家族史等一般临床资料，同时测定包括25-羟基维生素D\〖25(OH)D\〗等在内的生化指标，考察血清25(OH)D水平与各临床资料与生化指标的相关性。根据ARMD患病情况，分为ARMD组(231例)和非ARMD组(192例)，考察Vit-D缺乏和ARMD发生的相关性。

结果：血清25(OH)D水平与男性、户外光暴露时长呈显著正相关(r=0.439、0.664，均P<0.01)，与年龄、吸烟和饮酒则呈显著负相关(P<0.05)。二分类Logistic回归分析表明，Vit-D缺乏是ARMD发生的危险因素(OR=1.980，95%CI：1.829～2.201，P<0.01)，其他与ARMD发生有关的因素包括：年龄、性别、ARMD家族史、高血压、糖尿病、低密度脂蛋白胆固醇、户外光暴露时长>5h/d，且均为ARMD发生的危险因素(P<0.05)。

结论：营养失衡方面的Vit-D缺乏可能与ARMD发生相关，适当太阳光照射或膳食补充Vit-D可能有助于预防或改善ARMD的发生发展。

METHODS: A total of 423 cases of middle-aged and aged outpatients(age>45 years)who participated in the physical examination in ophthalmology clinic of Yuncheng First Hospital during February 2018 to February 2019 were included in the cross-sectional study. The clinical information(including sex, age, family history of ARMD, etc.)and biochemical indices(including 25-hydroxyvitamin D \〖25(OH)D\〗, etc.)were collected. The correlations between serum 25(OH)D level and clinical information, as well as biochemical indices, were analyzed. The outpatients were divided into ARMD group(231 cases)and non-ARMD group(192 cases)according to the ARMD situation in the study. The correlation between Vit-D deficiency and ARMD was analyzed.

RESULTS: Serum 25(OH)D level was positively correlated with the male, duration of outdoor light exposure(P<0.05), and negatively correlated with age, smoking and drinking(P<0.05). Binary Logistic regression analysis showed that Vit-D deficiency was a risk factor associated with ARMD(OR=1.980, 95% CI: 1.829-2.201, P<0.01). Other associated factors included age, sex, hypertension, diabetes, low-density lipoprotein cholesterol(LDL-C), and duration of outdoor light exposure >5h/d, which were also risk factors associated with ARMD.

CONCLUSION: Nutritional imbalance due to Vit-D deficiency might be associated with the occurrence of ARMD. Appropriate sun exposure or vit-D supplements could contribute to preventing the development of ARMD.