[关键词]
[摘要]
角膜新生血管是由于毛细血管或淋巴管侵入角膜所致，如不及时处理，将严重影响视力，角膜新生血管转基因老鼠模型的建立和应用为角膜新生血管机制的研究、抗血管药物的筛选和治疗方案的评估等提供了良好的平台，是一种非常有价值和潜力的动物模型。本文主要介绍转基因老鼠模型在角膜新生血管研究中的应用进展。
[Key word]
[Abstract]
The invasion of the cornea by capillary or lymphatic vessels leads to corneal neovascularization and if not handled in time, it will seriously affect vision, the establishment and application of transgenic mouse models of corneal neovascularization provides a good platform for the study of corneal neovascularization mechanism, the screening of antiangiogenic drugs and the evaluation of treatments. Transgenic mouse model of corneal neovascularization is a very valuable and potential animal model. This paper mainly introduces the application of transgenic mouse models in the research of corneal neovascularization.
[中图分类号]
[基金项目]
国家自然科学基金资助(No.81660158, 81400372); 江西省自然科学基金重大项目(No.20161ACB21017); 江西省重点研发项目重大项目(No.20151BBG70223); 江西省青年科学基金(No.20151BAB215016); 江西省教育厅重点项目(No.GJJ160020); 江西省卫计委科技计划面上项目(No.20175116)
