目的：探讨P50型EX-PRESS引流钉结合生物羊膜植入术在原发性开角型青光眼(POAG)中的治疗效果。

方法：选择2013-03/2019-01收治的POAG患者96例96眼为研究对象，以随机数字表法将患者分为观察组和对照组各48例，对照组单纯植入P50型EX-PRESS引流钉，观察组在对照组基础上结合生物羊膜植入术治疗，观察两组滤过泡情况，术前、术后7d，1、3mo的眼压、视网膜神经纤维厚度(RNFLT)变化，并发症发生情况及手术成功率。

结果：观察组术后3mo功能性滤过泡占比显著高于同期对照组(P<0.05)； 两组术前眼压、RNFLT均无差异(P>0.05)，观察组术后7d，1、3mo的眼压及RNFLT均明显低于同期对照组(P<0.05)； 观察组与对照组并发症发生率分别为12%、25%(P>0.05)； 观察组与对照组手术成功率分别为96%、75%(P<0.05)。

结论：POAG应用P50型EX-PRESS引流钉结合生物羊膜植入术治疗，疗效满意，能改善术后滤过泡情况，降低眼压及RNFLT，安全性佳，手术成功率高。

METHODS: Totally 96 cases of 96 eyes with POAG and who treated from March 2013 to January 2019 were selected as the research objects, and the patients were divided into the observation group and the control group by the random number table method, with 48 cases in each group. The control group was implanted with P50 EX-PRESS drainage nail only, while the observation group were treated with biological amniotic membrane implantation on the basis of the control group. Then, the changes of intraocular pressure, retinal nerve fiber thickness(RNFLT), complications and success rate of operation before operation and after the operation for 7d, 1mo and 3mo of two groups of patients were observed.

RESULTS: The proportion of functional filtering blebs after operation for 3mo in the observation group was significantly higher than that in the control group(P<0.05). There was no difference in preoperative intraocular pressure and RNFLT between the two groups(P>0.05). The intraocular pressure and RNFLT after operation for 7d, 1mo and 3mo in the observation group were significantly lower than those in the control group(P<0.05). The incidence of complications in the observation group and the control group were 12% and 25% respectively(P>0.05). The success rates of operation in observation group and control group were 96% and 75% respectively(P<0.05).

CONCLUSION:The application of P50 EX-PRESS drainage nail combined with biological amniotic membrane implantation for POAG, which the clinical effects are satisfactory, and which can improve the condition of filtering blebs, reduce intraocular pressure and RNFLT, thus it has good safety and high success rate.