目的：探讨视网膜血管直径对不同年龄人群动脉硬化的影响。

方法： 以参加2014年(第四次)健康体检且参加了臂踝脉搏波传导速度(baPWV)检测和眼底彩色照相检测者作为观察对象。根据世界卫生组织的年龄划分标准将研究对象分为3组：18～44岁组、45～59岁组和≥60岁组。首先采用多元线性回归分别分析总人群及不同年龄组人群视网膜中央动脉直径(CRAE)和视网膜动静脉直径比值(AVR)与baPWV的关联； 其次采用多因素Logistic回归模型分别分析总人群CRAE和不同年龄组人群AVR对动脉硬化(baPWV≥14.00m/s)的影响。

结果：CRAE和AVR随着年龄的增加而减小。多元线性回归分析，在45～59岁组和≥60岁组人群中CRAE和AVR与baPWV均呈负线性相关，CRAE和AVR每增加1单位，baPWV分别减小0.01、0.02、1.99和5.58m/s。多因素Logistic回归分析，在45～59岁组和≥60岁组人群中，CRAE每增加1μm，发生动脉硬化的风险均减小，其OR值(95%CI)分别为0.99(0.98～0.99)和0.98(0.97～0.99)。

结论：在45～59岁组和≥60岁组人群中，CRAE和AVR与动脉僵硬度呈负线性相关，它们的增加是发生动脉硬化的保护因素。

METHODS: Participants who took part in the 2014(fourth)physical examination and brachial-ankle pulse wave velocity(baPWV)and fundus color photography were observed. According to the WHO criteria of age, participants were divided into 3 groups by age: 18-44 years old group, 45-59 years old group and above 60 years old group. Multiple linear regression analysis was used to analyze the association between central retinal artery equivalent(CRAE)and arteriole-to-venule ratio(AVR)with baPWV in the total participants and then stratified by age. Multivariate Logistic regression model was use to analysis the influence of CRAE on arteriosclerosis(baPWV≥14.00m/s)in the total participants and then stratified by age.

RESULTS: CRAE and AVR decrease with age, in the non-atherosclerotic people. In multivariate linear regression analysis, CRAE and AVR were defeat correlated with baPWV in the 45-59 years old group and above 60 years old group. For each increase of 1 unit of CRAE and AVR, baPWV decreased by 0.01m/s, 0.02m/s, 1.99m/s and 5.58m/s, respectively. In multivariate Logistic regression analysis, the risk of arteriosclerosis decreased with the increase of CRAE by 1μm in the 45-59 years group and above 60 years old group. The OR values(95% CI)were 0.99(0.98-0.99)and 0.98(0.97-0.99), respectively.

CONCLUSION: In the 45-59 years old group and above 60 years old group, CRAE and AVR were negatively correlated with arterial stiffness, and their increase was the protective factor of arteriosclerosis.