目的：探讨视网膜内界膜移植治疗大孔径黄斑裂孔的疗效。

方法：对2016-03/2018-03在我院进行玻璃体切割手术治疗的大孔径(>700μm)特发性黄斑裂孔患者35例资料进行回顾性分析，其中A组(17例)患者行常规玻璃体切割联合内界膜剥除，B组(18例)患者行玻璃体切割联合内界膜移植术，术后随诊3～6mo，对术前、术后3mo的裂孔闭合率、BCVA进行比较。

结果：术后3mo A组裂孔闭合率为65%，B组裂孔闭合率为100%(P<0.05)； 术后3mo A组BCVA较术前显著提高(提高2行及以上)者占35%，B组较术前显著提高者占78%(P<0.05)。

结论：内界膜移植可提高大孔径特发性黄斑裂孔的术后裂孔闭合率，在一定程度上改善术后视功能，是一种安全有效的手术方式。

METHODS: Totally 35 patients with large macular hole(>700μm)underwent vitrectomy in our hospital from March 2016 to March 2018 were retrospectively analyzed, in which group A(17 patients)underwent vitrectomy and internal limiting membrane peeling generally, group B(18 patients)underwent vitrectomy and internal limiting membrane transplantation. The best corrected visual acuity(BCVA)and macular hole closure rate were performed preoperative and 3mo postoperative.

RESULTS: The macular hole closure rate in group A was 65% at 3mo safter surgery, and macular hole closure rate in group B was 100% at 3mo after surgery(P<0.05). The rate of BCVA of A group which were significantly improved at 3mo postoperative(increase by 2 lines or more)compared preoperative is 35%, and the rate of BCVA of B group is 78%(P<0.05).

CONCLUSION: Internal limiting membrane transplantation can improve the closure rate of large macular hole and visual function after surgery in a certain extent. It is a safe and effective surgical method.