[关键词]
[摘要]
干眼是指任何原因造成的泪液质或量异常或动力学异常，导致泪膜稳定性下降，并伴有眼部不适和(或)眼表组织病变特征的多种疾病的总称。干眼是一种多因素疾病，受年龄、环境因素影响较大。其中氧化应激因素与年龄相关性干眼关系密切。本文将基于动物实验研究，通过建立氧化应激实验动物模型，并监测眼表组织氧化损伤的生物标志物及抗氧化防御物水平，指出氧化应激在干眼中的作用。另外，一些介入性实验研究表明，氧化应激可能是干眼局部治疗的直接靶点。某些物质可以有效降低氧化应激损伤，从而达到治疗干眼的效果。近年来对氧化应激的进一步研究发现其在干眼中具有越来越重要的作用，为针对氧化应激的临床干预提供了依据。
[Key word]
[Abstract]
Dry eye syndrome refers to a general term for various diseases in which tear fluid quality orabnormality or kinetic abnormality is caused by any cause, resulting in decreased tear film stability, accompanied by ocular discomfort and/or ocular surface tissue lesion characteristics. Dry eye syndrome is a multifactorial disease that is greatly affected by age and environmental factors. Among them, oxidative stress is closely related to age-related dry eye. In this article, based on animal experiments, the role of oxidative stress in dry eye syndrome was pointed out by establishing animal models of oxidative stress and monitoring the levels of biomarkers and antioxidant defenses indicative of oxidative damage in ocular surface tissue. In addition, some interventional studies have shown that oxidative stress may be a direct target for local treatment of dry eye. Certain substances may effectively reduce oxidative stress damage, thereby achieving the effect of treating dry eye. Further research on oxidative stress in recent years has shown that oxidative stress has an increasingly important role in dry eye, providing a basis for clinical intervention against oxidative stress.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81660158,81400372)
