目的：应用光学相干断层扫描增强深部成像技术比较早期活动性Graves眼病患者与健康者黄斑中心凹下不同脉络膜分层厚度的差异。

方法：选取2017-12/2019-05在我院确诊的早期活动性Graves眼病患者(GO组)和年龄、性别相匹配的健康体检者各31例62眼(对照组)，所有受检者均进行屈光度、最佳矫正视力(BCVA)、眼压、眼球突出度、EDI-OCT等检查，比较两组受检者黄斑中心凹下脉络膜厚度(SFCT)、脉络膜大血管层厚度(LCVT)、脉络膜毛细血管层/中血管层厚度(MCVT)的差异。

结果：两组受检者等效球镜度数、BCVA、眼轴均无明显差异，但GO组受检者眼压(17.22±2.67mmHg)、眼球突出度(15.44±0.92mm)、SFCT(315.79±14.99μm)、LCVT(234.66±14.90μm)均显著高于对照组(13.35±1.54mmHg、12.90±1.00mm、239.00±12.67μm、159.16±13.30μm)(均P<0.05)，而两组受检者MCVT无差异(81.13±7.46μm vs 80.13±7.63μm，P>0.05)。

结论：早期活动性Graves眼病患者SFCT、LCVT增厚，MCVT无明显变化，提示应用EDI-OCT测量SFCT和LCVT对于评估早期活动性Graves眼病具有一定的参考价值。

METHODS:From December 2017 to May 2019, patients with early active Graves ophthalmopathy diagnosed in our hospital(GO group)and 31 patients(62 eyes)with age and sex matched healthy physical examination(control group)were selected. Diopter, best-corrected visual acuity(BCVA), intraocular pressure, exophthalmos, EDI-OCT and other examinations were performed on all the subjects. The differences of macular central concave choroidal thickness(SFCT), choroidal macrovascular layer thickness(LCVT)and choroidal capillary layer/middle vascular layer thickness(MCVT)between the two groups were compared.

RESULTS: There was no significant difference in equivalent spherical lens power, BCVA and eye axis between the two groups. However, the IOP(17.22±2.67mmHg), exophthalmos(15.44±0.92mm), SFCT(315.79±14.99μm), LCVT(234.66±14.90μm)in GO group were significantly higher than those in control group(13.35±1.54mmHg, 12.90±1.00mm, 239.00±12.67μm, 159.16±13.30μm)(all P<0.05), but there was no significant difference in MCVT between the two groups(81.13±7.46μm vs 80.13±7.63μm, P>0.05).

CONCLUSION: SFCT and LCVT in patients with early active Graves ophthalmopathy are thickened, and MCVT has no obvious change, suggesting that EDI-OCT measurement of SFCT and LCVT has certain reference value for evaluating early active Graves ophthalmopathy.