目的：对比研究LASEK术中弃留上皮瓣治疗高度近视的手术疗效。

方法：回顾性分析高度近视患者58例115眼，根据手术方式分为，LASEK留瓣组30例59眼，LASEK弃瓣组28例56眼。观察两组患者术后疼痛感、裸眼视力、角膜haze、上皮愈合时间。

结果：留瓣组和弃瓣组术后1d疼痛积分分别为1.64±0.64、1.57±0.57分，术后2d为0.83±0.49、0.84±0.56分，术后3d为0.36±0.48、0.34±0.47分； 两组不同时间疼痛积分无差异(P>0.05)。留瓣组和弃瓣组术后1wk裸眼视力分别为0.15±0.06、0.12±0.05，术后1mo时为0.032±0.004、0.041±0.003，术后3mo时为0.018±0.004、0.022±0.005； 两组不同时间裸眼视力无差异(P>0.05)。术后1、3mo，角膜haze 0.5～1级发生率差异均无统计学意义(P>0.05)； 角膜2级haze发生率差异均有统计学意义(P<0.05)； 留瓣组和弃瓣组上皮愈合时间分别为4.22±0.30、3.89±0.32d(P<0.05)。两组患者上皮延迟愈合数分别为0眼、6例10眼(P<0.05)。

结论：留瓣与弃瓣术后裸眼视力恢复无明显差异，角膜刺激症状相似。弃瓣组上皮愈合较快，但弃瓣组角膜haze 2级发生率稍高，上皮延迟愈合和愈合不良较多。因此，对于高度近视行LASEK手术时建议留瓣。

METHODS: Retrospective analysis of 58 patients(115 eyes)with high myopia received LASEK were selected and divided into reserving the epithelial flap group(30 patients, 59 eyes)and removing epithelial flap group(28 patients, 56 eyes)according to the order of the alternating vists. The changes of corneal irritation, epithelial healing time,uncorrected visual acuity and the occurrence of haze after surgery were observed.

RESULTS:Postoperative 1d, 2d, 3d, respectively, the pain score of the two groups were 1.64±0.64, 1.57±0.57; 0.83±0.49, 0.84±0.56; 0.36±0.48, 0.34±0.47, respectively, the differences were not significant(P>0.05). Postoperative 1wk, 1mo, 3mo, respectively, the uncorrected visual acuity of two group was 0.15±0.06, 0.12±0.05; 0.032±0.004, 0.041±0.003; 0.018±0.004, 0.022±0.005, and the differences were not significant(P>0.05). After 1mo, 3mo of surgery, the differences of the haze less than grade one of the two group, respectively, and were not significant(P>0.05), the differences of the haze of grade two of the two groups, respectively, and the differences were significant(P<0.05). The epithelial healing time of the two groups were 4.22±0.30d, 3.89±0.32d(P<0.05). The number of epithelial delayed healing of two groups was 0 eye and 10 eyes(P<0.05).

CONCLUSION:It was similar both the changes of corneal irritation and uncorrected visual acuity of two groups,the rate of level two haze was higher in removing epithelial flap group. The time of healing of epithelium was quick than reserving the epithelial flap group,but the rate of delayed healing and poor healing of epithelium was higher than reserving the epithelial flap group. Therefore, for high myopia, it is worthy of clinical application of reserving the epithelial flap by LASEK.