目的：分析无明显视力下降的糖尿病患者与正常人黄斑区视网膜厚度的差异。

方法：选取2018-04/2019-06在我院确诊为2型糖尿病且无明显视力下降(最佳矫正视力≥0.8)的患者40例79眼为观察组，同期选取健康志愿者64例119眼为对照组。采用3D OCT获得两组受检者黄斑区9个区域平均视网膜厚度和黄斑区中心凹视网膜厚度(CRT)、平均视网膜厚度(ART)及视网膜体积(TV)，并分析两组受检者之间的差异。

结果：观察组患者CRT、ART、TV(193.99±14.58μm、291.07±12.24μm、8.22±0.35mm³)均明显高于对照组受检者(187.38±12.24μm、280.54±8.71μm、7.92±0.25mm³)，且观察组患者黄斑区9个区域平均视网膜厚度均明显高于对照组受检者，差异均有统计学意义(P<0.05)。

结论：无明显视力下降的2型糖尿病患者早期黄斑区视网膜厚度和体积较正常人增加。

METHODS: Totally 40 cases(79 eyes)with type 2 diabetes without significant decrease of visual acuity(best corrected visual acuity, BCVA ≥0.8)in our hospital from April, 2018 to June, 2019 were enrolled as observation group and 64 cases(119 eyes)normal persons were enrolled as control group. The average retinal thickness in nine areas of macula, central retinal thickness(CRT), average retinal thickness(ART)and total volume(TV)of all patients were determined by optical coherence tomography(OCT), and the difference of average retinal thickness in nine areas of macula, CRT, ART and TV among them were compared.

RESULTS: The CRT, ART and TV(193.99±14.58μm, 291.07±12.24μm, 8.22±0.35mm³)in the observation group were significantly higher than those in the control group(187.38±12.24μm, 280.54±8.71μm, 7.92±0.25mm³), and the average retinal thickness in nine areas of macula in the observation group was significantly higher than that in the control group(P<0.05).

CONCLUSION: Compared with normal persons, macular retinal thickness and TV are significantly thickened in early stage of type 2 diabetes.