[关键词]
[摘要]
近视是目前世界上最常见的人类眼部疾病之一。微小RNA(microRNAs，miRNAs)是一类长度约20～25个核苷酸的非蛋白编码的小分子单链RNA，能广泛参与基因转录后水平的调控，与机体的生理病理过程密切相关。近年来，miRNAs在近视发生发展中的调控作用引起了研究人员的广泛关注。本文就miRNAs在近视发生发展过程中的调控作用及可能涉及的通路进行综述，以期为近视发生发展的机制研究和分子生物学诊断提供思路。
[Key word]
[Abstract]
Myopia is one of the most common eye diseases in the world. MicroRNAs(miRNAs)are small, non-protein-coded single-stranded RNAs with a length of about 20-25 nucleotides,which are widely involved in the process of post-transcriptional regulation of many physiological and pathological processes of organisms. It has attracted extensive attention for the regulation role of miRNAs in the process of induction and development of myopia in recent years. This article reviews the regulatory role and related signal pathways of miRNAs in the development of myopia. It will provide highlights for the understanding of molecular mechanism of myopia and benefit for potential molecular diagnosis of myopia in the future.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.81603421); 山东省重点研发计划(No.2019GSF108252)
