目的：通过光学相干断层成像(OCT)检测高度近视合并青光眼患者视神经纤维层厚度的变化规律。

方法：选取2017-01/12于我院进行治疗的高度近视合并青光眼患者80例160眼作为观察组，并选择同期于我院进行体检的健康志愿者60例120眼作为对照组。采用OCT分析所有受检者视神经纤维层厚度。

结果：与对照组受检者相比，观察组患者鼻侧、颞上、鼻下、鼻上、颞下及全周平均视神经纤维层厚度均降低，而颞侧视神经纤维层厚度升高(P<0.05)，且观察组中屈光度-10.00～-11.00D的患者鼻侧、颞上、鼻下、鼻上、颞下及全周平均视神经纤维层厚度均显著高于屈光度≥-12.00D的患者(P<0.05)。Spearman相关分析结果显示，观察组患者屈光度的绝对值与鼻侧、颞上、鼻下、颞下及全周平均厚度视神经纤维层厚度呈负相关，与颞侧视神经纤维层厚度呈正相关。

结论：高度近视合并青光眼患者除颞侧外各象限视神经纤维层变薄。

METHODS: Totally 160 eyes of 80 patients with high myopia and glaucoma who were treated in our hospital during 2017-01/12 were selected as the observation group, and 60 healthy volunteers(120 eyes)who underwent physical examination in our hospital during the same period were selected as the control group. OCT was used to analyze the thickness of optic nerve fibers in both groups.

RESULTS: Subjects compared with control group, the observation group of patients with nasal side, temporal, under the nose, nasal, under the temporal and the week on the average thickness of the optic nerve fiber layer is reduced, and the temporal side nerve fiber layer thickness increased(P<0.05), and in the observation group diopter -10.00 to -11.00D in patients with nasal side, temporal, under the nose, nose, and the temporal and the week, on average, the optic nerve fiber layer thickness were significantly higher than that of diopter≥-12.00D patients(P<0.05). Spearman correlation analysis results showed that the absolute value of diopter was negatively correlated with the mean thickness of optic nerve fiber layer in the nasal side, upper temporal quadrant, lower nasal side, upper nasal side, lower temporal and the whole circumference, and positively correlated with the thickness of optic nerve fiber layer in the lateral temporal optic nerve.

CONCLUSION: In patients with high myopia combined with glaucoma, the optic nerve fibers in all quadrants except the temporal side become thinner.